期刊
NUTRIENTS
卷 14, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nu14071497
关键词
conservatives; food additives; sodium benzoate; neurodegenerative diseases; depression
There are conflicting research results on the safety of sodium benzoate, with some studies suggesting its potential use in treating various diseases and others pointing out its harmful effects.
Currently, due to the large number of reports regarding the harmfulness of food additives, more and more consumers follow the so-called clean label trend, i.e., prefer and choose the least-processed food products. One of the compounds known as a preservative with a high safety profile is sodium benzoate. While some studies show that it can be used to treat conditions such as depression, pain, schizophrenia, autism spectrum disorders, and neurodegenerative diseases, others report its harmfulness. For example, it was found to cause mutagenic effects, generate oxidative stress, disrupt hormones, and reduce fertility. Due to such disparate results, the purpose of this study is to comprehensively discuss the safety profile of sodium benzoate and its potential use in neurodegenerative diseases, especially in autism spectrum disorder (ASD), schizophrenia, major depressive disorder (MDD), and pain relief.
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