期刊
MATERIALS
卷 15, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ma15103664
关键词
zirconia implants; surface structure; mean bone loss; bone-to-implant contact; osteoblasts; cell spreading; gene expression
This review analyzed and correlated the findings of zirconia implants in clinical, preclinical, and in vitro cell studies in relation to surface structure. The results showed no correlation between surface structure and the observed effects in all three study types. Micro-structured surfaces showed lower mean bone loss in clinical studies, while smooth surfaces enhanced cell spreading and cytoskeletal formation in cell studies. Standardized procedures for human, animal, and in vitro studies are needed to further examine the results.
Background: The purpose of this review was to analyze and correlate the findings for zirconia implants in clinical, preclinical and in vitro cell studies in relation to surface structure. Methods: Electronic searches were conducted to identify clinical, preclinical and in vitro cell studies on zirconia implant surfaces. The primary outcomes were mean bone loss (MBL) for clinical studies, bone-to-implant contact (BIC) and removal torque (RT) for preclinical studies and cell spreading, cell proliferation and gene expression for cell studies. The secondary outcomes included comparisons of data found for those surfaces that were investigated in all three study types. Results: From 986 screened titles, 40 studies were included for data extraction. In clinical studies, only micro-structured surfaces were investigated. The lowest MBL was reported for sandblasted and subsequently etched surfaces, followed by a sinter and slurry treatment and sandblasted surfaces. For BIC, no clear preference of one surface structure was observable, while RT was slightly higher for micro-structured than smooth surfaces. All cell studies showed that cell spreading and cytoskeletal formation were enhanced on smooth compared with micro-structured surfaces. Conclusions: No correlation was observed for the effect of surface structure of zirconia implants within the results of clinical, preclinical and in vitro cell studies, underlining the need for standardized procedures for human, animal and in vitro studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据