期刊
CANCER LETTERS
卷 368, 期 2, 页码 209-229出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.02.047
关键词
Radiotherapy; Immunotherapy; Hyperthermia; Heat shock response; Heat shock protein
类别
资金
- Deutsche Forschungsgemeinschaft [CRC914]
- Elite Netzwerk Bayern (iTarget Graduate Program)
- Heuer-Stiftung
- Deutsche Forschungsgemeinschaft (IRTG)
Radiotherapy represents an essential treatment option for the majority of cancer patients in different stages of their disease. Physical achievements of the recent years led to the implementation of high precision treatment planning procedures, and image-guided dose delivery is current state of the art. Yet, radiotherapy still faces several limitations with cancer intrinsic radioresistance being a key driver of therapeutic failure. Accordingly, the mechanisms orchestrating radioresistance and their therapeutic targeting by combined modality approaches are in the center of attention of numerous radiation oncologists. In the present review, we summarize and discuss therapeutic approaches that exploit the heat shock response, either by hyperthermia or by pharmacological heat shock protein inhibition, in combination with radiotherapy. These strategies appear particularly promising, since they sensitize cancer cells to irradiation-induced cell death and at the same time have proven the potential to promote systemic anti-tumor immune mechanisms, which may target not only locally surviving tumor cells, but also distant out-of-field metastases. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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