期刊
JOURNAL OF COSMETIC DERMATOLOGY
卷 21, 期 10, 页码 5066-5072出版社
WILEY
DOI: 10.1111/jocd.14964
关键词
erythema reactions; minimal erythema dose; skin barrier; skin biophysical properties; ultraviolet radiation; ultraviolet sensitivity
类别
This study found that skin biophysical properties have significant effects on sensitivity to UV radiation. By investigating indicators such as skin hydration and TEWL, individual susceptibility to UV damage can be predicted.
Background The levels of burning susceptibility to ultraviolet (UV) radiations are affected by various factors, including Fitzpatrick skin types, skin color, sex, and ethnicity. However, studies on the relationship between skin biophysical properties and erythemal responses to UV radiations are rare. Objective This study aimed to investigate biophysical properties of the skin that determined individual skin sensitivity to UV radiation. Methods As an indicator of skin sensitivity to UV radiation, Korean women were subjected to minimal erythema dose (MED) testing. The skin biophysical properties, such as skin hydration, transepidermal water loss (TEWL), were measured. MED were also evaluated in further variations in the skin, including barrier disruption. Results A significant negative correlation was observed between TEWL and MED. With an increase in TEWL, that represents reduced skin barrier function, skin UV sensitivity also increased. Artificial alteration of skin conditions also changed erythemal response to UV radiation. When the skin barrier was disrupted, MED significantly decreased, indicating increased skin UV sensitivity. It is hypothesized that the altered penetration of UV radiation into the stratum corneum under the respective skin conditions caused different erythema reactions. Conclusion For the first time in a clinical study, the skin biophysical properties, including skin barrier function, were found to have significant effects on skin sensitivity to UV radiation. This finding could help predict individual susceptibility to UV damage. Therefore, skincare products that improve skin conditions associated with UV sensitivity, as well as sunscreen are important for protection against the hazards of UV radiation.
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