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London Pancreas Workshop 2014 Edited by Hemanth Kocher Volume 14, Issue 2, Supplement 1, Pages e1-e6 (March-April 2014) Abstracts
[Anonymous]
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DEVELOPMENT (2012)
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DEVELOPMENTAL BIOLOGY (2012)
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JOURNAL OF CLINICAL INVESTIGATION (2012)
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JOURNAL OF CLINICAL INVESTIGATION (2012)
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Oliver Strobel et al.
GASTROENTEROLOGY (2010)
Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells
Shujie Zhao et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
John P. Morris et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Fabrizio Thorel et al.
NATURE (2010)
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
Meritxell Rovira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The what, where, when and how of Wnt/β-catenin signaling in pancreas development
L. Charles Murtaugh
Organogenesis (2010)
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
John P. Morris et al.
NATURE REVIEWS CANCER (2010)
Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7
Jing He et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
Sharon Y. Gidekel Friedlander et al.
CANCER CELL (2009)
Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients
Chanjuan Shi et al.
CLINICAL CANCER RESEARCH (2009)
Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth
Myriam Solar et al.
DEVELOPMENTAL CELL (2009)
Age-Dependent Decline in beta-Cell Proliferation Restricts the Capacity of beta-Cell Regeneration in Mice
Shuen-Ing Tschen et al.
DIABETES (2009)
Adaptive β-cell Proliferation Is Severely Restricted With Advanced Age
Matthew M. Rankin et al.
DIABETES (2009)
Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice
Claire Bonal et al.
GASTROENTEROLOGY (2009)
Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia
Guanglu Shi et al.
GASTROENTEROLOGY (2009)
KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin
Chanjuan Shi et al.
MOLECULAR CANCER RESEARCH (2009)
EGF receptor in pancreatic β-cell mass regulation
Paivi Miettinen et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
β cells can be generated from endogenous progenitors in injured adult mouse pancreas
Xiaobo Xu et al.
CELL (2008)
Metalloproteinases and cell fate - Notch just ADAMs anymore
Eric T. Sawey et al.
CELL CYCLE (2008)
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells
Jared S. Burlison et al.
DEVELOPMENTAL BIOLOGY (2008)
CDK inhibitors: Cell cycle regulators and beyond
Arnaud Besson et al.
DEVELOPMENTAL CELL (2008)
Hedgehog signals in pancreatic differentiation from embryonic stem cells: revisiting the neglected
J. K. Mfopou et al.
DIFFERENTIATION (2008)
Overexpression of interleukin-1β in the murine pancreas results in chronic pancreatitis
Frederic Marrache et al.
GASTROENTEROLOGY (2008)
Stabilization of β-catenin induces pancreas tumor formation
Patrick W. Heiser et al.
GASTROENTEROLOGY (2008)
Hedgehog spikes pancreas regeneration
David A. Cano et al.
GASTROENTEROLOGY (2008)
Hedgehog signaling is required for effective regeneration of exocrine pancreas
Volker Fendrich et al.
GASTROENTEROLOGY (2008)
Notch signaling is required for exocrine regeneration after acute pancreatitis
Jens T. Sivere et al.
GASTROENTEROLOGY (2008)
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood
Toshihiko Masui et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Reprogramming pancreatic exocrine cells to β-cells
[Anonymous]
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
De La O. Jean-Paul et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
Nils Habbe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
Akari Inada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression
Jennifer K. Colby et al.
NEOPLASIA (2008)
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Qiao Zhou et al.
NATURE (2008)
Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway
Eric T. Sawey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Basic-liver, pancreas, and biliary tract
Oliver Strobel et al.
GASTROENTEROLOGY (2007)
Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III
Takeshi Miyatsuka et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex
Toshihiko Masui et al.
GENES & DEVELOPMENT (2007)
Hypothetical progression model of pancreatic cancer with origin in the centroacinar-acinar compartment
Irene Esposito et al.
PANCREAS (2007)
Inactivation of srnad4 accelerates KrasG12D-Mediated pancreatic neoplasia
Kyoko Kojima et al.
CANCER RESEARCH (2007)
Delayed progression of pancreatic intraepithelial neoplasia in a conditional KrasG12D mouse model by a selective cyclooxygenase-2 inhibitor
Hitoshi Funahashi et al.
CANCER RESEARCH (2007)
A multipotent progenitor domain guides pancreatic organogenesis
Qiao Zhou et al.
DEVELOPMENTAL CELL (2007)
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
Liqin Zhu et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Sox9 coordinates a transcriptional network in pancreatic progenitor cells
F. C. Lynn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
Hana Algul et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Suppression of transforming growth factor β signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations
Stefan Wildi et al.
GUT (2007)
Metaplasia and transdifferentiation: from pure biology to the clinic
Jonathan M. W. Slack
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Negative regulation of TGF-β receptor/Smad signal transduction
Susumu Itoh et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Preexisting pancreatic to acinar cell, but not islet β cell, regeneration
Biva M. Desai et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
Catherine Carriere et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
β cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo
Oliver Strobel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinorna by k-Ras Oncogenes in adult mice
Carmen Guerra et al.
CANCER CELL (2007)
BMP4-BMPR1A signaling in β cells is required for and augments glucose-stimulated insulin secretion
Joan Goulley et al.
CELL METABOLISM (2007)
SOX9 is required for maintenance of the pancreatic progenitor cell pool
Philip A. Seymour et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Wnt/β-catenin signaling is required for development of the exocrine pancreas
James M. Wells et al.
BMC DEVELOPMENTAL BIOLOGY (2007)
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen
Herbert Archer et al.
GASTROENTEROLOGY (2006)
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
Jennifer M. Halbleib et al.
GENES & DEVELOPMENT (2006)
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
Nabeel Bardeesy et al.
GENES & DEVELOPMENT (2006)
Notch signaling in stem cell systems
Shigeru Chiba
STEM CELLS (2006)
Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
Gamze Kilic et al.
DEVELOPMENTAL DYNAMICS (2006)
Timing and expression pattern of carbonic anhydrase II in pancreas
Akari Inada et al.
DEVELOPMENTAL DYNAMICS (2006)
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation
Takeshi Miyatsuka et al.
GENES & DEVELOPMENT (2006)
Detection of overexpressed COX-2 in precancerous lesions of hamster pancreas and lungs by molecular imaging: Implications for early diagnosis and prevention
Hildegard M. Schuller et al.
CHEMMEDCHEM (2006)
Stabilization of β-catenin impacts pancreas growth
PW Heiser et al.
DEVELOPMENT (2006)
BMP4 regulates pancreatic progenitor cell expansion through Id2
H Hua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Dysplasia and cancer in a large multicenter cohort of patients with Barrett's esophagus
Prateek Sharma et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2006)
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
N Bardeesy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Hedgehog signaling in the normal and diseased pancreas
Hany Kayed et al.
PANCREAS (2006)
Transforming growth factor-β pathway:: Role in pancreas development and pancreatic disease
SG Rane et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2006)
PTF1 is an organ-specific and notch-independent basic helix-loop-helix complex containing the mammalian suppressor of hairless (RBP-J) or its paralogue, RBP-L
TM Beres et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Mist1-Kras(G12D) knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma
DA Tuveson et al.
CANCER RESEARCH (2006)
β-Catenin is essential for pancreatic acinar but not islet development
LC Murtaugh et al.
DEVELOPMENT (2005)
Classification of types of intraductal papillary-mucinous neoplasm of the pancreas:: a consensus study
T Furukawa et al.
VIRCHOWS ARCHIV (2005)
Prox1 activity controls pancreas morphogenesis and participates in the production of secondary transition pancreatic endocrine cells
JF Wang et al.
DEVELOPMENTAL BIOLOGY (2005)
The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas
MA Hale et al.
DEVELOPMENTAL BIOLOGY (2005)
Pancreas-specific deletion of β-catenin reveals Wnt-dependent and Wnt-independent functions during development
J Dessimoz et al.
CURRENT BIOLOGY (2005)
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
BZ Stanger et al.
CANCER CELL (2005)
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
AL Means et al.
DEVELOPMENT (2005)
Apoptosis of human endothelial cells is accompanied by proteolytic processing of latent TGF-β binding proteins and activation of TGF-β
VT Solovyan et al.
CELL DEATH AND DIFFERENTIATION (2005)
Morphogenetic plasticity of adult human pancreatic islets of Langerhans
AM Jamal et al.
CELL DEATH AND DIFFERENTIATION (2005)
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis
JY Qian et al.
CANCER RESEARCH (2005)
Trp53R172H and KraSG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
SR Hingorani et al.
CANCER CELL (2005)
Precursors to invasive pancreatic cancer
A Maitra et al.
ADVANCES IN ANATOMIC PATHOLOGY (2005)
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
JN Jensen et al.
GASTROENTEROLOGY (2005)
Activation of nestin-positive duct stem (NPDS) cells in pancreas upon neogenic motivation and possible cytodifferentiation into insulin-secreting cells from NPDS cells
SY Kim et al.
DEVELOPMENTAL DYNAMICS (2004)
Increased expression of NF-κB subunits in human pancreatic cancer cells
NM Chandler et al.
JOURNAL OF SURGICAL RESEARCH (2004)
PTF1α/p48 and cell proliferation
A Rodolosse et al.
GASTROENTEROLOGY (2004)
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
F Esni et al.
DEVELOPMENT (2004)
Cystic neoplasms of the pancreas and tumor-like lesions with cystic features:: a review of 418 cases and a classification proposal
M Kosmahl et al.
VIRCHOWS ARCHIV (2004)
An illustrated consensus on the classification of pancreatic Intraepithelial neoplasia and intraductal papillary mucinous neoplasms
RH Hruban et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2004)
Inhibition of transforming growth factor β decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice
Y Nagashio et al.
LABORATORY INVESTIGATION (2004)
Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas
J Lardon et al.
VIRCHOWS ARCHIV (2004)
orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
DA Cano et al.
DEVELOPMENT (2004)
A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice
L Rosenberg et al.
ANNALS OF SURGERY (2004)
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Y Dor et al.
NATURE (2004)
Polymerization within a molecular-scale stereoregular template
T Serizawa et al.
NATURE (2004)
Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas
F Esni et al.
MECHANISMS OF DEVELOPMENT (2004)
Nestin expression in pancreatic exocrine cell lineages
A Delacour et al.
MECHANISMS OF DEVELOPMENT (2004)
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
AJ Aguirre et al.
GENES & DEVELOPMENT (2003)
Notch signaling controls multiple steps of pancreatic differentiation
LC Murtaugh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani et al.
CANCER CELL (2003)
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ
S Herzig et al.
NATURE (2003)
Dicer is essential for mouse development
E Bernstein et al.
NATURE GENETICS (2003)
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
SP Thayer et al.
NATURE (2003)
Combined activities of hedgehog signaling inhibitors regulate pancreas development
H Kawahira et al.
DEVELOPMENT (2003)
Signals for death and differentiation:: a two-step mechanism for in vitro transformation of adult islets of Langerhans to duct epithelial structures
AM Jamal et al.
CELL DEATH AND DIFFERENTIATION (2003)
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
J Hald et al.
DEVELOPMENTAL BIOLOGY (2003)
Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas
B Burghardt et al.
GUT (2003)
Expression of Sox transcription factors in the developing mouse pancreas
O Lioubinski et al.
DEVELOPMENTAL DYNAMICS (2003)
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Y Miyamoto et al.
CANCER CELL (2003)
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia
AL Means et al.
GASTROENTEROLOGY (2003)
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
NT van Heek et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Pancreatic stellate cells contribute to regeneration early after acute necrotising pancreatitis in humans
A Zimmermann et al.
GUT (2002)
Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood
HX Hui et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2002)
How cells change their phenotype
D Tosh et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
The role of PTF1-P48 in pancreatic acinar gene expression
SD Rose et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
CL Pin et al.
JOURNAL OF CELL BIOLOGY (2001)
Factors mediating the transdifferentiation of islets of Langerhans to duct epithelial-like structures
R Wang et al.
JOURNAL OF ENDOCRINOLOGY (2001)
Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
S Roy et al.
CURRENT BIOLOGY (2001)
Transdifferentiation of human islet cells in a long-term culture
BM Schmied et al.
PANCREAS (2001)
Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
HX Hui et al.
DIABETES (2001)
Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
H Zulewski et al.
DIABETES (2001)
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: Clinicopathologic and prognostic significance of matrilysin expression
H Yamamoto et al.
JOURNAL OF CLINICAL ONCOLOGY (2001)
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
M Wagner et al.
GENES & DEVELOPMENT (2001)
Intercellular signals regulating pancreas development and function
SK Kim et al.
GENES & DEVELOPMENT (2001)
P53-Dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas
CR Scoggins et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)
Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
I Rooman et al.
DIABETOLOGIA (2000)
Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
P Jacquemin et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Differentiation of islet cells in long-term culture
BM Schmied et al.
PANCREAS (2000)
Loss of TGF-β signaling contributes to autoimmune pancreatitis
KB Hahm et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
A Cano et al.
NATURE CELL BIOLOGY (2000)
Cyclooxygenase-2 expression in human pancreatic adenocarcinomas
MT Yip-Schneider et al.
CARCINOGENESIS (2000)
Transforming growth factor β induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells
Y Sayo et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
Immunohistochemical labeling for Dpc4 mirrors genetic status in pancreatic adenocarcinomas - A new marker of DPC4 inactivation
RE Wilentz et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Control sf endodermal endocrine development by Hes-1
J Jensen et al.
NATURE GENETICS (2000)
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