期刊
BIOMEDICAL OPTICS EXPRESS
卷 13, 期 7, 页码 4047-4057出版社
Optica Publishing Group
DOI: 10.1364/BOE.459486
关键词
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资金
- Royal Academy of Engineering [RF/201819/18/125]
- Wellcome Trust [203145/Z/16/Z]
- European Research Council [74119]
- Wellcome Trust [203145/Z/16/Z] Funding Source: Wellcome Trust
This study presents an all-optical ultrasound transducer for highly miniaturised applications. The transducer utilizes a dual-clad optical fibre for multimode light generation and single mode light reception. It demonstrates high-pressure ultrasound generation and reception, high image quality, and unprecedented miniaturisation, representing a new paradigm for minimally invasive imaging.
All-optical ultrasound (OpUS), where ultrasound is both generated and received using light, has emerged as a modality well-suited to highly miniaturised applications. In this work we present a proof-of-concept OpUS transducer built onto a single optical fibre with a highly miniaturised lateral dimension (<0.8 mm). A key innovation was to use a dual-clad optical fibre (DCF) to provide multimode light for ultrasound generation and single mode light for ultrasound reception. The transducer comprised a proximal section of DCF spliced to a short section of single mode fibre (SMF). Multimode light was outcoupled at the splice joint and guided within a square capillary to provide excitation for ultrasound generation. Whilst single mode light was guided to the distal tip of the SMF to a plano-concave microresonator for ultrasound reception. The device was capable of generating ultrasound with pressures >0.4 MPa and a corresponding bandwidth >27 MHz. Concurrent ultrasound generation and reception from the transducer enabled imaging via motorised pull-back allowing image acquisition times of 4 s for an aperture of 20 mm. Image resolution was as low as similar to 50 mu m and 190 mu m in the axial and lateral extents, respectively, without the need for image reconstruction. Porcine aorta was imaged ex vivo demonstrating detailed ultrasound images. The unprecedented level of miniaturisation along with the high image quality produced by this device represents a radical new paradigm for minimally invasive imaging. (C) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
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