Tunable Silver-Catalyzed Nitrene Transfer: From Chemoselectivity to Enantioselective C-H Amination

Transition-metal-catalyzed C-H aminations via nitrene transfer processes are powerful synthetic methods to construct valuable amines. Over the past decade, significant efforts in the field have resulted in an expansion in the utility of nitrene transfer chemistry, enabling the use of these carbon-nitrogen bond-forming reactions in complex organic molecule syntheses. This Perspective highlights efforts in silver-catalyzed nitrene transfer reactions that achieve chemo-, site-, and enantioselective transformations using simple N-dentate ligands that can serve as stepping stones for future investigations of other tunable C-H functionalizations.

Automated summary

Transition-metal-catalyzed C-H aminations via nitrene transfer processes are powerful synthetic methods to construct valuable amines. Recent efforts in silver-catalyzed nitrene transfer reactions have achieved chemo-, site-, and enantioselective transformations using simple N-dentate ligands. These findings serve as a foundation for future investigations of other tunable C-H functionalizations.