期刊
ACS CATALYSIS
卷 12, 期 7, 页码 3890-3896出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c00373
关键词
Nickel catalysis; alkene functionalization; carboamination; amine electrophile; diamine
资金
- Bristol Myers Squibb
- National Science Foundation [CHE-2102550]
- Camille Dreyfus Teacher-Scholar Program
- Kwanjeong Educational Foundation
- Xunta de Galicia
This study presents a versatile method for accessing differentially substituted 1,3- and 1,4-diamines through nickel-catalyzed three-component 1,2-carboamination of alkenyl amines. The reaction is efficient, regioselective, and compatible with a wide range of coupling partners, all performed at room temperature.
A versatile method to access differentially substituted1,3- and 1,4-diamines via nickel-catalyzed three-component 1,2-carboamination of alkenyl amines with aryl/alkenylboronic esternucleophiles and N-O electrophiles is reported. The reaction proceedsefficiently with free primary and secondary amines without needing adirecting auxiliary or protecting group and is enabled byfine-tuning theleaving group on the N-O reagent. The transformation is highlyregioselective and compatible with a wide range of coupling partners and alkenyl amine substrates, all performed at roomtemperature. A series of kinetic studies support a mechanism in which alkene coordination to the nickel catalyst is turnover-limiting.
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