期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-30006-2
关键词
-
资金
- NSFC [92156004, 21822105, 22001118]
- NSF of Jiangsu Province [BK20190281, BK20211555, BK20201245, BK20200300]
- Fundamental Research Funds for the Central Universities [020514380253, 020514380263]
- programs for high-level entrepreneurial and innovative talents introduction of Jiangsu Province
- Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University
In this work, a highly regio- and enantioselective Ni-catalysed migratory hydroarylation relay process has been achieved with the combination of two simple ligands, providing direct access to a wide range of structurally diverse chiral 1,1-diarylalkanes. The value of this strategy was further demonstrated by the Ni-catalysed migratory asymmetric 1,3-arylboration.
The design of a single complicated chiral ligand to well-promote each step of an asymmetric cascade reaction is sometimes a formidable challenge in transition metal catalysis. In this work, a highly regio- and enantioselective Ni-catalysed migratory hydroarylation relay process has been achieved with the combination of two simple ligands, one which accomplishes chain-walking and the other causing asymmetric arylation. This formal asymmetric C(sp(3))-H arylation provides direct access to a wide range of structurally diverse chiral 1,1-diarylalkanes, a structural unit found in a number of bioactive molecules. The value of this strategy was further demonstrated by the Ni-catalysed migratory asymmetric 1,3-arylboration. Migratory alkene isomerizations and cross-coupling reactions are both possible under nickel catalysis, but usually require different conditions. Here the authors show a combined protocol to isomerize a double bond and then, via an in-situ exchange of ligands, perform an enantioselective C(sp2)-C(sp3) cross-coupling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据