期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 19, 期 1, 页码 15-21出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2016.1258065
关键词
Valerianaceae; Valeriana jatamansi; valepotriates; isomers; cytotoxicity
资金
- NCET Foundation
- NSFC [81230090, 81522050]
- Shanghai Leading Academic Discipline Project [B906]
- Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]
- Scientific Foundation of Shanghai China [12401900801, 13401900101]
- National Major Project of China [2011ZX09307-002-03]
- National Key Technology R&D Program of China [2012BAI29B06]
Three new minor valepotriate isomers, jatamanvaltrates Z1 (1), Z2 (2), and Z3 (3), have been isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii.). Their structures were elucidated by extensive spectroscopic analysis, especially 2D NMR and ESI-MS/MSn. All isolated compounds displayed moderate cytotoxicity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines with IC50 values of 2.8-8.3M.
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