期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 18, 期 8, 页码 791-797出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2016.1158166
关键词
Cyperaceae; Scirpus yagara; chemical constituents; dehydrophyllodulcin; anti-inflammatory
资金
- National Natural Science Foundation of China [81173515]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
A new natural compound, dehydrophyllodulcin (1) was isolated from the tubers of Scirpus yagara, together with 11 known compounds. Among them, compounds 2, 5-8, and 10-12 were isolated from this plant for the first time. H-1 NMR, C-13 NMR, and 2D NMR data of compound 1 are first reported in this article, though it was synthesized in 1996. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and compared with literature information. Moreover, the anti-inflammatory effects of compounds 1, 3, 4, 6, and 9 against inflammatory cytokines production in Lipopolysaccharide - or Pam3csk4-stimulated macrophage RAW264.7 cells were evaluated by Enzyme-linked immunosorbent assay. And these compounds significantly inhibited the tumor necrosis factor (TNF)-, interleukin (IL)-6 productions in RAW264.7 cells, with IC50 values less than 20 mu M.
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