期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-29938-6
关键词
-
资金
- National Research Programs of China [2021YFF0701800]
- National Natural Science Foundation of China [U20A20254 L.C., 52072253 L.C., 21927803 Z.L., 52032008 Z.L.]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- 111 Project, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices
- Jiangsu Natural Science Fund for Distinguished Young Scholars [BK20211544]
- Jiangsu Social Development Project [BE2019658]
- Practice Innovation Program of Jiangsu Province [KYCX21_2947 N.Y.]
- China Postdoctoral Science Foundation [2021TQ0229]
- Suzhou Key Laboratory of Nanotechnology and Biomedicine
- Tang Scholarship of Soochow University
The researchers developed magnesium galvanic rods that continuously produce hydrogen and found that hydrogen can be used as an anti-cancer treatment. By implanting these rods into tumors, hydrogen molecules can be generated within the tumor, leading to tumor inhibition. This hydrogen therapy based on implantable metals may be a safe and effective cancer treatment.
The production of hydrogen inside cells can stimulate cell death. Here, the authors made magnesium galvanic rods that continuously produce hydrogen and result in tumor inhibition in vitro and in vivo. Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H-2 molecules within the tumor is challenging. Magnesium (Mg) and its alloys have been extensively used in the clinic as implantable metals. Here we develop, by decorating platinum on the surface of Mg rods, a Mg-based galvanic cell (MgG), which allows the continuous generation of H-2 in an aqueous environment due to galvanic-cell-accelerated water etching of Mg. By implanting MgG rods into a tumor, H-2 molecules can be generated within the tumor, which induces mitochondrial dysfunction and intracellular redox homeostasis destruction. Meanwhile, the Mg(OH)(2) residue can neutralize the acidic tumor microenvironment (TME). Such MgG rods with the micro-galvanic cell structure enable hydrogen therapy to inhibit the growth of tumors, including murine tumor models, patient-derived xenografts (PDX), as well as VX2 tumors in rabbits. Our research suggests that the galvanic cells for hydrogen therapy based on implantable metals may be a safe and effective cancer treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据