New conjugates of mycophenolic acid and their antiproliferative activity

The new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N-6-(-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a-h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.