Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination

Annual epidemics of seasonal influenza cause hundreds of thousands of deaths, high levels of morbidity, and substantial economic loss. Yet, global influenza circulation has been heavily suppressed by public health measures and travel restrictions since the onset of the COVID-19 pandemic. Notably, the influenza B/Yamagata lineage has not been conclusively detected since April 2020, and A(H3N2), A(H1N1), and B/Victoria viruses have since circulated with considerably less genetic diversity. Travel restrictions have largely confined regional outbreaks of A(H3N2) to South and Southeast Asia, B/Victoria to China, and A(H1N1) to West Africa. Seasonal influenza transmission lineages continue to perish globally, except in these select hotspots, which will likely seed future epidemics. Waning population immunity and sporadic case detection will further challenge influenza vaccine strain selection and epidemic control. We offer a perspective on the potential short- and long-term evolutionary dynamics of seasonal influenza and discuss potential consequences and mitigation strategies as global travel gradually returns to pre-pandemic levels. COVID-19 control measures have suppressed circulation of other infections including influenza. Here, the authors analyse WHO global influenza sequence and case report data and describe changes in the phylogenetic and geographic distribution of influenza lineages during the COVID-19 pandemic.

Automated summary

Since the onset of the COVID-19 pandemic, public health measures and travel restrictions have heavily suppressed global influenza circulation. The genetic diversity of seasonal influenza viruses has significantly decreased, with the influenza B/Yamagata lineage not conclusively detected. Travel restrictions have confined the circulation of different influenza viruses to specific regions, leading to a continuous decline in global transmission of seasonal influenza, except in select hotspots that may seed future epidemics. Additionally, the selection of influenza vaccine strains and epidemic control face challenges due to waning population immunity and sporadic case detection.