4.8 Article

Rational design of hairpin RNA excited states reveals multi-step transitions

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Visualizing a protonated RNA state that modulates microRNA-21 maturation

Jared T. Baisden et al.

Summary: Research has shown that the precursor of oncogenic microRNA-21 can form a pH-dependent ensemble that reshuffles its structure spontaneously, leading to enhanced efficiency in Dicer processing. This suggests that the efficiency of microRNA biogenesis may be encoded in the intrinsic dynamic ensemble of primary and precursor microRNAs, allowing regulation in response to environmental and cellular stimuli.

NATURE CHEMICAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids

Bei Liu et al.

Summary: Recent advances in solution-state nuclear magnetic resonance (NMR) methods, integrated with computational techniques, have improved the ability to probe the dynamic ensembles of DNA and RNA, leading to new mechanistic insights into gene expression and regulation.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states

Yanjiao Wang et al.

Summary: NH groups in proteins or nucleic acids are challenging for chemical shift prediction. A lookup table linking base pair triplets to experimental chemical shifts can predict imino chemical shifts of RNAs accurately, even for non-canonical motifs. Combining this prediction with NMR relaxation dispersion experiments helps verify the presence of excited states in RNA motifs.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Structural resolution of switchable states of a de novo peptide assembly

William M. Dawson et al.

Summary: De novo protein design has been rapidly evolving, with recent advancements allowing for the creation of peptide structures that can exist in multiple alpha-helical-bundle states under the same conditions. This design demonstrates a frustrated system with interconverting states, influenced by steric interactions and the hydrophobic effect. Further studies using biophysical experiments, NMR, and MD simulations have characterized the unique properties of this peptide.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA

Lorenzo Baronti et al.

NATURE (2020)

Review Biochemistry & Molecular Biology

RNA Dynamics by NMR Spectroscopy

Maja Marusic et al.

CHEMBIOCHEM (2019)

Review Cell Biology

The roles of structural dynamics in the cellular functions of RNAs

Laura R. Ganser et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Cell Biology

RNA Switches for Synthetic Biology

Calvin M. Schmidt et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

Article Multidisciplinary Sciences

Dynamic basis for dG.dT misincorporation via tautomerization and ionization

Isaac J. Kimsey et al.

NATURE (2018)

Article Multidisciplinary Sciences

Synthetic RNA-based logic computation in mammalian cells

Satoshi Matsuura et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

Separating Dipolar and Chemical Exchange Magnetization Transfer Processes in 1H-CEST

Tairan Yuwen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemistry & Molecular Biology

Rational design of proteins that exchange on functional timescales

James A. Davey et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biotechnology & Applied Microbiology

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemical Research Methods

Multi-objective optimization for RNA design with multiple target secondary structures

Akito Taneda

BMC BIOINFORMATICS (2015)

Article Biochemistry & Molecular Biology

Characterizing excited conformational states of RNA by NMR spectroscopy

Bo Zhao et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes

Isaac J. Kimsey et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

Hierarchy of RNA Functional Dynamics

Anthony M. Mustoe et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)

Review Genetics & Heredity

A challenge for miRNA: multiple isomiRs in miRNAomics

Li Guo et al.

Article Biochemical Research Methods

Chemical exchange in biomacromolecules: Past, present, and future

Arthur G. Palmer

JOURNAL OF MAGNETIC RESONANCE (2014)

Article Chemistry, Multidisciplinary

Broccoli: Rapid Selection of an RNA Mimic of Green Fluorescent Protein by Fluorescence-Based Selection and Directed Evolution

Grigory S. Filonov et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Multidisciplinary Sciences

Invisible RNA state dynamically couples distant motifs

Janghyun Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

De novo design of a synthetic riboswitch that regulates transcription termination

Manja Wachsmuth et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Multidisciplinary Sciences

NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers

Ashok Sekhar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Chemistry, Multidisciplinary

Synthetic mammalian riboswitches based on guanine aptazyme

Yoko Nomura et al.

CHEMICAL COMMUNICATIONS (2012)

Article Chemistry, Physical

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

Levi C. T. Pierce et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)

Article Chemistry, Multidisciplinary

Probing Transient Hoogsteen Hydrogen Bonds in Canonical Duplex DNA Using NMR Relaxation Dispersion and Single-Atom Substitution

Evgenia N. Nikolova et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Visualizing transient low-populated structures of RNA

Elizabeth A. Dethoff et al.

NATURE (2012)

Review Multidisciplinary Sciences

Functional complexity and regulation through RNA dynamics

Elizabeth A. Dethoff et al.

NATURE (2012)

Review Microbiology

Bacterial RNA thermometers: molecular zippers and switches

Jens Kortmann et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Article Multidisciplinary Sciences

De novo automated design of small RNA circuits for engineering synthetic riboregulation in living cells

Guillermo Rodrigo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biochemistry & Molecular Biology

Engineering Biological Systems with Synthetic RNA Molecules

Joe C. Liang et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

Transient Hoogsteen base pairs in canonical duplex DNA

Evgenia N. Nikolova et al.

NATURE (2011)

Article Multidisciplinary Sciences

RNA Mimics of Green Fluorescent Protein

Jeremy S. Paige et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

Thermodynamic characterization of naturally occurring RNA tetraloops

Justin P. Sheehy et al.

Article Biochemistry & Molecular Biology

The Centrality of RNA

Phillip A. Sharp

Article Biochemistry & Molecular Biology

The Dynamic Landscapes of RNA Architecture

Jose Almeida Cruz et al.

Review Biochemistry & Molecular Biology

Frameworks for Programming Biological Function through RNA Parts and Devices

Maung Nyan Win et al.

CHEMISTRY & BIOLOGY (2009)

Article Multidisciplinary Sciences

The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data

Marc Parisien et al.

NATURE (2008)

Article Chemistry, Multidisciplinary

Conformational dynamics of bistable RNAs studied by time-resolved NMR spectroscopy

Boris Fuertig et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Review Chemistry, Multidisciplinary

Characterization of the dynamics of biomacromolecules using rotating-frame spin relaxation NMR spectroscopy

Arthur G. Palmer et al.

CHEMICAL REVIEWS (2006)

Review Biotechnology & Applied Microbiology

RNA synthetic biology

FJ Isaacs et al.

NATURE BIOTECHNOLOGY (2006)

Review Biochemistry & Molecular Biology

Non-coding RNA

JS Mattick et al.

HUMAN MOLECULAR GENETICS (2006)

Review Cell Biology

Understanding alternative splicing: Towards a cellular code

AJ Matlin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Chemistry, Physical

Accelerated molecular dynamics: A promising and efficient simulation method for biomolecules

D Hamelberg et al.

JOURNAL OF CHEMICAL PHYSICS (2004)

Article Chemistry, Multidisciplinary

An NMR experiment for the accurate measurement of heteronuclear spin-lock relaxation rates

DM Korzhnev et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)

Article Biochemistry & Molecular Biology

Imino proton exchange and base-pair kinetics in RNA duplexes

K Snoussi et al.

BIOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

A test of the model to predict unusually stable RNA hairpin loop stability

T Dale et al.