4.4 Review

Management of chemotherapy dose intensity for metastatic colorectal cancer

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Review Chemistry, Medicinal

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Asal Jalal Abadi et al.

Summary: Curcumin, isolated from Curcuma longa, has potent tumor-suppressor activity and can decrease the adverse impacts of cisplatin (CP) while enhancing its antitumor activity. Curcumin reduces ROS levels to prevent apoptosis in normal cells, inhibits inflammation, and reduces various toxicities caused by CP. Additionally, curcumin potentiates CP cytotoxicity and suppresses tumor-promoting pathways to prevent drug resistance.

PHYTOTHERAPY RESEARCH (2022)

Review Oncology

The prevalence of frailty among breast cancer patients: a systematic review and meta-analysis

Shurui Wang et al.

Summary: The presence of frailty in breast cancer patients is associated with a higher risk of hospitalization, mortality, and falls. The prevalence of frailty in these patients varies considerably, with a pooled prevalence of 43% in this meta-analysis. Factors such as treatment method, frailty scales, age, and region were found to be associated with the prevalence of frailty in breast cancer patients.

SUPPORTIVE CARE IN CANCER (2022)

Review Engineering, Biomedical

Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy

Xiaoxuan Xu et al.

Summary: By regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM, intratumor ECM barriers can be effectively overcome, leading to improved drug delivery and anticancer efficacy.

ADVANCED HEALTHCARE MATERIALS (2022)

Review Oncology

Coping Strategies in Elderly Colorectal Cancer Patients

Keyla Vargas-Roman et al.

Summary: This article summarizes the impact of coping strategies on the quality of life of colorectal cancer patients. The results suggest that coping strategies can help patients adapt and overcome the stress caused by the disease. For elderly patients, learning coping strategies may improve their quality of life after cancer diagnosis. However, more research is needed to validate this hypothesis, as there is limited randomized evidence available.

CANCERS (2022)

Review Pharmacology & Pharmacy

A framework for economic evaluation of therapeutic drug monitoring-guided dosing in oncology

Daniel Erku et al.

Summary: The traditional approach to individualize chemotherapy doses based on body surface area may result in suboptimal drug concentrations for some patients. With the shift towards targeted molecular therapies in oncology, dosing is typically fixed for all patients. It is important to evaluate the economic efficiency and impact on patient outcomes before implementing TDM-guided dosing in oncology settings.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

Review Oncology

Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor

Kelly M. Hotchkiss et al.

Summary: GBM is difficult to eradicate with immunotherapy and chemotherapy, and different doses and timing of chemotherapy may affect tumor eradication efficacy.

JOURNAL OF NEURO-ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Is there scope for better individualisation of anthracycline cancer chemotherapy?

Benedetta C. Sallustio et al.

Summary: Anthracyclines are commonly used in the treatment of various cancers, but their primary toxicities are myelosuppression and cardiotoxicity. Children have lower drug clearance rates, leading to increased risk of cardiotoxicity. Population pharmacokinetic models in adults have not sufficiently addressed the impact of various factors on cardiotoxicity.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Review Chemistry, Multidisciplinary

Recent advances in lipid-engineered multifunctional nanophytomedicines for cancer targeting

Mayank Handa et al.

Summary: Cancer is a leading cause of death worldwide, with current treatments considered suboptimal due to pathophysiological challenges. Nanotechnology has enabled the development of phytomedicine-based nanostructured delivery systems for more targeted cancer therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Oncology

Prevalence and Predictive Factors for Upfront Dose Reduction of the First Cycle of First-Line Chemotherapy in Older Adults with Metastatic Solid Cancer: Korean Cancer Study Group (KCSG) Multicenter Study

In Gyu Hwang et al.

Summary: Upfront dose reduction (UDR) of palliative chemotherapy is often performed for older adults with metastatic solid cancer, with approximately 60% of patients receiving UDR. Poor performance status (PS) and living without a spouse were identified as predictive factors of UDR. Patients with UDR showed better tolerance to chemotherapy compared to those with standard doses.

CANCERS (2021)

Article Gastroenterology & Hepatology

Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer over age 80: a retrospective study

Hiroyuki Hisada et al.

Summary: This study assessed the efficacy of chemotherapy and prognostic factors among patients aged 80 years and older with metastatic colorectal cancer. Results showed that these super-elderly patients had lower overall survival compared to younger patients, and chemotherapy did not significantly improve survival in this age group. Carcinoembryonic antigen levels and prognostic nutritional index were identified as independent prognostic factors in super-elderly patients with mCRC.

BMC GASTROENTEROLOGY (2021)

Review Urology & Nephrology

Kidney injury and disease in patients with haematological malignancies

Frank Bridoux et al.

Summary: Patients with haematological cancer are at a higher risk of kidney injury, either as a direct result of the malignancy or due to treatment-related effects. It is common for cancer patients, especially those with haematological malignancies, to experience acute kidney injury (AKI) which can be caused by the underlying blood disorder.

NATURE REVIEWS NEPHROLOGY (2021)

Review Oncology

Angiogenesis as a hallmark of solid tumors-clinical perspectives

Jamal Majidpoor et al.

Summary: Angiogenesis is a crucial step in tumorigenesis, with abnormal tumor vasculature leading to hypoxia and acidity in the tumor microenvironment, enhancing tumor aggression. High interstitial fluid pressure can act as a barrier for drug delivery, contributing to tumor resistance to therapy. Combination of anti-angiogenesis therapy with other modalities is a promising strategy for advanced cancers.

CELLULAR ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities

Rabin Neupane et al.

Summary: Transdermal drug delivery is a promising alternative for cancer treatment, reducing dose frequency and severity of adverse effects. It can be used for localized tumor treatment and sustained delivery of low-dose chemotherapeutics or vaccines. However, challenges remain in designing effective transdermal formulations.

PHARMACEUTICS (2021)

Review Oncology

Antineoplastic dosing in overweight and obese cancer patients: an Associazione Italian Oncologia Medica (AIOM)/Associazione Medici Diabetology (AMD)/Societa Italiana Endocrinologia (SIE)/Societa Italiana Farmacologia (SIF) multidisplinary consensus position paper

N. Silvestris et al.

Summary: Most anticancer molecules are administered based on body size, which poses challenges in pharmacokinetic data for heavy patients. Obesity has outpaced advancements in tailored drug dosing methods and strategies, leading to a lack of pharmacokinetic data on obese patients. Experts provide a consensus statement for appropriate cytotoxic chemotherapy and new biological cancer drug dosing in obese patients.

ESMO OPEN (2021)

Article Oncology

The Influence of Adjuvant Chemotherapy Dose Intensity on Five-Year Outcomes in Resected Colon Cancer: A Single Centre Retrospective Analysis

Suganija Lakkunarajah et al.

Summary: Evidence suggests that achieving a dose intensity > 80% in adjuvant colon cancer treatment improves survival rates.

CURRENT ONCOLOGY (2021)

Article Oncology

Update in version 2021 of CSCO guidelines for colorectal cancer from version 2020

Caixia Dong et al.

CHINESE JOURNAL OF CANCER RESEARCH (2021)

Article Oncology

Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer

Yojiro Hashiguchi et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Medicine, Research & Experimental

Neurotoxicity of antineoplastic drugs: Mechanisms, susceptibility, and neuroprotective strategies

Claudia Pellacani et al.

ADVANCES IN MEDICAL SCIENCES (2020)

Review Geriatrics & Gerontology

Geriatric management of older patients with multimorbidity

Taro Kojima et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2020)

Review Pharmacology & Pharmacy

The rationale of dose-response curves in selecting cancer drug dosing

Jennifer H. Martin et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Review Oncology

Promising New Agents for Colorectal Cancer

Satya Das et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2018)

Article Oncology

Causes of death among cancer patients

N. G. Zaorsky et al.

ANNALS OF ONCOLOGY (2017)

Review Oncology

Review of therapeutic drug monitoring of anticancer drugs part 1-Cytotoxics

Angelo Paci et al.

EUROPEAN JOURNAL OF CANCER (2014)

Article Medicine, General & Internal

Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer

Fotios Loupakis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Chemistry, Medicinal

FOLFOX 4 Combined with Herbal Medicine for Advanced Colorectal Cancer: A Systematic Review

Menghua Chen et al.

PHYTOTHERAPY RESEARCH (2014)

Article Gastroenterology & Hepatology

Management of locally advanced and metastatic colon cancer in elderly patients

Peter C. Kurniali et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Oncology

Antiangiogehic Drugs for Colorectal Cancer: Exploring New Possibilities

Renata Ferrarotto et al.

CLINICAL COLORECTAL CANCER (2013)

Article Public, Environmental & Occupational Health

Prevalence of Multiple Chronic Conditions Among US Adults: Estimates From the National Health Interview Survey, 2010

Brian W. Ward et al.

PREVENTING CHRONIC DISEASE (2013)

Article Gastroenterology & Hepatology

Neoadjuvant and adjuvant therapy in relation to surgery for colorectal liver metastases

Antoine Brouquet et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2012)

Article Cell Biology

The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity

Wing Lam et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Article Oncology

Impact of Chemotherapy Dose Intensity on Cancer Patient Outcomes

Gary H. Lyman

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2009)

Article Oncology

Potential regional differences for the tolerability profiles of fluoropyrimidines

Daniel G. Haller et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

Meeting Abstract Oncology

A phase I trial of RX-0201 (AKT anti-sense) in patients with an advanced cancer

J. Marshall et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Review Oncology

Perspectives in the treatment of colorectal cancer

H Ozer et al.

SEMINARS IN ONCOLOGY (2004)