4.4 Review

Management of chemotherapy dose intensity for metastatic colorectal cancer

期刊

ONCOLOGY LETTERS
卷 23, 期 5, 页码 -

出版社

SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2022.13261

关键词

chemotherapy dose intensity; metastatic colorectal cancer; prognosis; efficacy; safety; clinical application

类别

向作者/读者索取更多资源

Chemotherapy dose intensity is a significant parameter in antitumor clinical medication, affecting treatment efficacy, disease prognosis, and patient safety.
Chemotherapy dose intensity is a momentous parameter of antitumor clinical medication. In certain clinical trials, the actual application dose of the chemotherapeutic drugs is frequently different from the prescribed dose. The chemotherapy dose intensity completed in different trials is also variable, which has an impact on the treatment efficacy, disease prognosis and patient safety. When these agents are tested in the population, chemotherapy reduction and delay or failure to complete the planned cycle constantly occur due to age, performance status, adverse reactions and other reasons, resulting in the modification of the chemotherapy dose intensity. The present review analyzed the correlation between the chemotherapy dose intensity and the incidence of adverse reactions, the treatment efficacy and disease prognosis in clinical trials of metastatic colorectal cancer. Moreover, the clinical applications of chemotherapy dose intensity were discussed. Based on individual differences, the present review analyzed the clinical trials that examined the efficacy of the chemotherapy dose intensity in different patient populations. The conclusions suggested that different populations require a specific dose intensity to reduce treatment toxicity without affecting the curative effect.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据