Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma

Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment.

Automated summary

Glioma is a common invasive primary tumor of the central nervous system, and treatment resistance remains a problem. Non-coding RNAs play a role in the mechanisms of treatment resistance. This review discusses the pathways by which microRNAs and long non-coding RNAs affect resistance to chemotherapy and radiotherapy, and offers potential therapeutic options for future glioma treatment.