期刊
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
卷 15, 期 5, 页码 1024-1048出版社
SPRINGER
DOI: 10.1007/s12265-022-10241-0
关键词
Angiogenesis; Arteriogenesis; Myocardial infarction; Myocardial revascularization; Coronary artery bypass graft; Percutaneous coronary intervention
This review analyzes the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both coronary artery disease (CAD) and coronary revascularization, aiming to better understand their significance in the clinical arena and potential therapeutic use.
Surgical myocardial revascularization is associated with long-term survival benefit in patients with multivessel coronary artery disease. However, the exact biological mechanisms underlying the clinical benefits of myocardial revascularization have not been elucidated yet. Angiogenesis and arteriogenesis biologically leading to vascular collateralization are considered one of the endogenous mechanisms to preserve myocardial viability during ischemia, and the presence of coronary collateralization has been regarded as one of the predictors of long-term survival in patients with coronary artery disease (CAD). Some experimental studies and indirect clinical evidence on chronic CAD confirmed an angiogenetic response induced by myocardial revascularization and suggested that revascularization procedures could constitute an angiogenetic trigger per se. In this review, the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both CAD and coronary revascularization is analyzed with the aim to better elucidate their significance in the clinical arena and potential therapeutic use.
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