4.7 Article

DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Targeting p53 for the treatment of cancer

Michael J. Duffy et al.

Summary: Dysfunction of the TP53 gene is prevalent in human malignancies, making it an attractive target for new anticancer drugs. Two strategies, reactivating mutant p53 and inhibiting the interaction between wild-type p53 and MDM2/MDM4, are being explored in clinical trials. The development of compounds targeting these strategies has the potential to revolutionize cancer treatment.

SEMINARS IN CANCER BIOLOGY (2022)

Article Gastroenterology & Hepatology

DNA Methylation Profiling of Human Hepatocarcinogenesis

Gabriela Hernandez-Meza et al.

Summary: This study identified DNA methylation changes during the transition from preneoplastic lesions to early HCC and potential epigenetic gatekeepers. Additionally, methylation changes in cirrhotic tissue were found to correlate with clinical outcomes.

HEPATOLOGY (2021)

Review Pharmacology & Pharmacy

Current developments of targeting the p53 signaling pathway for cancer treatment

Jing Huang

Summary: p53, one of the most well-studied tumor suppressors, is mutated or deleted in half of all cancers. Despite over forty years of research, designing therapeutics targeting the p53 pathway remains extremely challenging. Current efforts include developing p53-based gene therapy and targeted therapies, as well as exploiting the immunogenicity of p53 protein for cancer immunotherapy.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Cell Biology

p53 and Tumor Suppression: It Takes a Network

Anthony M. Boutelle et al.

Summary: TP53 tumor suppressor gene is the most frequently mutated gene in human cancer, playing a crucial role in inhibiting tumorigenesis by transcriptionally regulating target genes. Recent studies have revealed new pathways and transcriptional targets downstream of p53 in regulating genomic integrity, metabolism, redox biology, stemness, and non-cell autonomous signaling in tumor suppression.

TRENDS IN CELL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Hepatocellular carcinoma: old friends and new tricks

Eunsun Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Biochemistry & Molecular Biology

The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma

Pradeep Kumar Rajan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

p53: 800 million years of evolution and 40 years of discovery

Arnold J. Levine

NATURE REVIEWS CANCER (2020)

Article Gastroenterology & Hepatology

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Ryan A. Hlady et al.

HEPATOLOGY (2019)

Article Gastroenterology & Hepatology

Epidemiology and Management of Hepatocellular Carcinoma

Laura Kulik et al.

GASTROENTEROLOGY (2019)

Review Oncology

Epigenetics of hepatocellular carcinoma

Tan Boon Toh et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2019)

Review Oncology

Precision diagnosis and treatment of liver cancer in China

Jing Fu et al.

CANCER LETTERS (2018)

Editorial Material Oncology

The molecular pathology of cancer: from pan-genomics to post-genomics

David G. Huntsman et al.

JOURNAL OF PATHOLOGY (2018)

Review Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2018)

Review Gastroenterology & Hepatology

Epigenetic mechanisms regulating the development of hepatocellular carcinoma and their promise for therapeutics

Faisal Saeed Khan et al.

HEPATOLOGY INTERNATIONAL (2017)

Article Gastroenterology & Hepatology

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Daniela Sia et al.

GASTROENTEROLOGY (2017)

Article Oncology

Cancer Statistics in China, 2015

Wanqing Chen et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

Article Gastroenterology & Hepatology

Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications

Amedeo Sciarra et al.

JOURNAL OF HEPATOLOGY (2016)

Review Biotechnology & Applied Microbiology

Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma

Mankgopo M. Kgatle et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Review Multidisciplinary Sciences

Function and information content of DNA methylation

Dirk Schuebeler

NATURE (2015)

Article Computer Science, Interdisciplinary Applications

Curbing false discovery rates in interpretation of genome-wide expression profiles

Bernard Ycart et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2014)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Biochemistry & Molecular Biology

Epigenetic aberrations during oncogenesis

Maria Hatziapostolou et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Review Oncology

DNA methylation and cancer: ghosts and angels above the genes

Nino Sincic et al.

CURRENT OPINION IN ONCOLOGY (2011)

Review Biochemistry & Molecular Biology

Cancer epigenetics reaches mainstream oncology

Manuel Rodriguez-Paredes et al.

NATURE MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Epigenetic modifications and human disease

Anna Portela et al.

NATURE BIOTECHNOLOGY (2010)

Review Biotechnology & Applied Microbiology

Epigenetic drivers and genetic passengers on the road to cancer

Carla Sawan et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2008)

Review Biochemistry & Molecular Biology

Epigenetic gene silencing in cancer: the DNA hypermethylome

Manel Esteller

HUMAN MOLECULAR GENETICS (2007)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Medicine, General & Internal

Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation

JG Herman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)