4.7 Article

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

The emerging roles of circRNAs in cancer and oncology

Lasse S. Kristensen et al.

Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Article Medicine, Research & Experimental

hsa_circ_0005358 suppresses cervical cancer metastasis by interacting with PTBP1 protein to destabilize CDCP1 mRNA

Yixuan Cen et al.

Summary: This study identified a downregulated circular RNA (hsa_circ_0005358) derived from the host gene Gli1 in cervical cancer tissues, which suppressed the migration and invasion abilities of cervical cancer cells by interacting with polypyrimidine tract-binding protein 1 (PTBP1), ultimately reducing cancer metastasis.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

Article Oncology

Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer

Jiehua He et al.

Summary: This study found that circHERC4 was significantly upregulated in colorectal cancer tissues, associated with lymph node metastasis and advanced tumor grade, and correlated with worse survival. Silencing circHERC4 inhibited proliferation and migration of aggressive CRC cell lines and reduced metastasis in vivo. Mechanistically, circHERC4 inactivated the tumor suppressor miR-556-5p, leading to activation of the CTBP2/E-cadherin pathway promoting tumor metastasis in CRC.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Review Oncology

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

Deborah Blythe Doroshow et al.

Summary: PD-L1 expression is currently the best predictor of responsiveness to immune-checkpoint inhibitors, despite challenges in clinical use such as variability in different assays and cut-off points, as well as the lack of prospective comparisons with clinical outcomes. Nevertheless, several immunohistochemical assays have been approved for clinical use, with implications for pathology services and potential impacts on clinical outcomes. Comparison of FDA-approved PD-L1 assays, understanding of the varying implications of PD-L1 expression across different tumour types, and exploration of novel approaches to optimize its clinical utility are important topics for further research and practice.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer

Yanbin Liu et al.

Summary: The study revealed a positive correlation between CMTM6 and HuR expression in most types of cancer, where HuR stabilizes CMTM6 mRNA through direct association with AREs and upregulates CMTM6 expression, which can be inhibited by MS-444. In HuR-overexpressing cancer cells, abundant cell surface PD-L1 inhibits immune activation of T cells, but treatment with MS-444 relieves immune suppression and stimulates immune responses. Ectopic HuR accelerates allograft tumor progression in vivo, which can be greatly reduced by simultaneous administration of MS-444, suggesting the potential of combining HuR inhibitor with PD-1/PD-L1 antibodies for cancer immunotherapy.

ONCOGENE (2021)

Article Cell Biology

PURPL represses autophagic cell death to promote cutaneous melanoma by modulating ULK1 phosphorylation

Shuo Han et al.

Summary: The study identified a long noncoding RNA called PURPL as an oncogene in melanoma cells, promoting cell proliferation and migration while inhibiting autophagic cell death by modulating the activity of the autophagy initiation factor ULK1. This suggests that targeting PURPL could be a potential intervention strategy for melanoma therapy.

CELL DEATH & DISEASE (2021)

Article Oncology

Long Noncoding RNA VESTAR Regulates Lymphangiogenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing VEGFC mRNA Stability

Yali Wang et al.

Summary: This study revealed a novel lncRNA-guided mechanism of lymph node metastasis in ESCC, in which VESTAR played a key role in lymphatic metastasis. This may provide a potential target for the treatment of ESCC lymphatic metastasis.

CANCER RESEARCH (2021)

Article Medicine, Research & Experimental

Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer

Jiaxin Chen et al.

Summary: circRHOBTB3 is downregulated in colorectal cancer tissues and cell lines, overexpression of circRHOBTB3 suppresses tumor metastasis through the HuR/PTBP1 axis in CRC.

THERANOSTICS (2021)

Review Cell Biology

The expanding regulatory mechanisms and cellular functions of circular RNAs

Ling-Ling Chen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Circular RNA: metabolism, functions and interactions with proteins

Wei-Yi Zhou et al.

MOLECULAR CANCER (2020)

Article Multidisciplinary Sciences

Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

Nina Ripin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

Article Biochemistry & Molecular Biology

Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes

Yajun Chen et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Biochemistry & Molecular Biology

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

Marta Pabis et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biotechnology & Applied Microbiology

Translation of the circular RNA circ-catenin promotes liver cancer cell growth through activation of the Wnt pathway

Wei-Cheng Liang et al.

GENOME BIOLOGY (2019)

Review Oncology

Pembrolizumab in cervical cancer: latest evidence and clinical usefulness

Edith Borcoman et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2017)

Review Oncology

Immunotherapy in Gynecologic Cancers: Are We There Yet?

Janelle B. Pakish et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2017)

Review Medicine, General & Internal

Antiangiogenic therapy in oncology: current status and future directions

Gordon C. Jayson et al.

LANCET (2016)

Review Chemistry, Medicinal

Targeting Programmed Cell Death Using Small-Molecule Compounds to Improve Potential Cancer Therapy

Bowen Ke et al.

MEDICINAL RESEARCH REVIEWS (2016)

Review Oncology

Circular RNA and miR-7 in Cancer

Thomas B. Hansen et al.

CANCER RESEARCH (2013)

Article Multidisciplinary Sciences

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Paul Nicklin et al.

Review Medicine, General & Internal

MECHANISMS OF DISEASE Cell Death

Richard S. Hotchkiss et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Cell Biology

The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

Ralph J. DeBerardinis et al.

CELL METABOLISM (2008)

Review Cell Biology

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Medicine, Research & Experimental

Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4

Lucile Espert et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Review Biochemistry & Molecular Biology

HuR and mRNA stability

CM Brennan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2001)