4.7 Review

Targeting the Nucleosome Acidic Patch by Viral Proteins: Two Birds with One Stone?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

Eric F. Pettersen et al.

Summary: UCSF ChimeraX is a powerful visualization program with enhanced performance and graphics, offering new tools and analysis features, support for various areas like virtual reality, and improved ease of use, along with an app store for researchers to contribute new tools.

PROTEIN SCIENCE (2021)

Article Biochemistry & Molecular Biology

Principles of nucleosome recognition by chromatin factors and enzymes

Robert K. McGinty et al.

Summary: The recent cryoelectron microscopy structures of chromatin complexes show that many chromatin proteins interact with their nucleosome substrate by using similar arginine anchor and variant arginine interactions. These proteins target specific histone structures on the nucleosome surface and can also interact with and distort nucleosomal DNA for complementary binding.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure

Vincenzo R. Lobbia et al.

Summary: The regulation of chromatin biology relies heavily on manipulating the smallest subunit, the nucleosome, and molecular interactions must be tuned to navigate the complexity of the dense nuclear environment. This review analyzes the interplay between nucleosome-protein interactions and higher-order chromatin structure, shedding light on how these factors operate in a complex environment. Additionally, characteristics of nucleosome-protein interactions that can lead to phase separation of chromatin are reviewed, highlighting the challenges in characterizing interactions beyond the nucleosome.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Review Virology

HIV Capsid and Integration Targeting

Alan N. Engelman

Summary: Integration of retroviral reverse transcripts into host chromosomes is crucial for efficient viral gene expression and inheritance. Different virus-host interactions impact the non-random integration sites, with lentiviruses like HIV evolving to infect cells efficiently by usurping cellular nuclear import mechanisms. Specific interactions between HIV capsid protein and host proteins play a key role in dictating integration site targeting, highlighting potential antiviral drug targets.

VIRUSES-BASEL (2021)

Review Virology

Cytomegalovirus Infections in Children with Primary and Secondary Immune Deficiencies

Caroline M. Bateman et al.

Summary: Cytomegalovirus (CMV) causes significant morbidity and mortality in immunosuppressed children by establishing host latency that leads to periodic reactivation, especially in immunocompromised hosts. Early identification and prevention strategies are crucial for managing CMV infections in primary immunodeficient hosts. Treatments, including CMV immunotherapy, play a vital role in the clinical management of CMV in children with secondary immunodeficiency.

VIRUSES-BASEL (2021)

Review Biophysics

Structures and Functions of Chromatin Fibers

Ping Chen et al.

Summary: The structure and dynamics of chromatin play a crucial role in controlling DNA accessibility and processes like transcription, replication, and repair. Recent research progress has shed light on the organization and function of chromatin fibers, highlighting the dynamic regulation and its implications in biological functions and diseases.

ANNUAL REVIEW OF BIOPHYSICS, VOL 50, 2021 (2021)

Review Microbiology

Deconstructing virus condensation

Nora Lopez et al.

Summary: Viruses have evolved precise mechanisms to utilize cellular pathways for replication, forming liquid-like viral factories (VFs) through a biomolecular condensation process. During infection, a positive feedback cycle leads to an increase in transcription and translation within VFs. Understanding viral biomolecular condensation may lead to novel therapeutics and provide insights into cellular gene regulation through phase separation.

PLOS PATHOGENS (2021)

Article Cell Biology

Viruses in the Nucleus

Bojana Lucic et al.

Summary: Viral infection relies on the virus's ability to generate progeny, with viruses transversing the nuclear envelope barrier through the nuclear pore complex to replicate and ensure persistent infections within the host genome.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Interphase epichromatin: last refuge for the 30-nm chromatin fiber?

Peng Xu et al.

Summary: Interphase epichromatin refers to the chromatin surface located adjacent to the interphase nuclear envelope, which is believed to be heterochromatic with a high density of exposed acidic patches. The development of cryo-electron microscopy (Cryo-EM) allows for the visualization of chromatin in a close-to-native situation, revealing the structure of ELCS and its relationship with interphase epichromatin. The study of ELCS through Cryo-ET is crucial for understanding the chromatin organization near the nuclear envelope.

CHROMOSOMA (2021)

Review Microbiology

Pathogenesis of human cytomegalovirus in the immunocompromised host

Paul Griffiths et al.

Summary: HCMV infection is usually controlled by a vigorous immune response, but can cause serious organ diseases when the immune system is compromised. Significant progress has been made in understanding HCMV infection and disease, including defining the dynamics of viral replication and evaluating new antiviral drugs and vaccines.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

Control of Viral Latency by Episome Maintenance Proteins

Alessandra De Leo et al.

TRENDS IN MICROBIOLOGY (2020)

Review Biochemistry & Molecular Biology

Beads on a string-nucleosome array arrangements and folding of the chromatin fiber

Sandro Baldi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Review Microbiology

Tuning the Orchestra: HCMV vs. Innate Immunity

Valentina Dell'Oste et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

Svetlana O. Dodonova et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma

Matthew J. McBride et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding

Aleksandra Skrajna et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Cell Biology

Dynamic chromatin organization without the 30-nm fiber

Kazuhiro Maeshima et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Molecular recognition of nucleosomes by binding partners

Seyit Kale et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Nucleosome structure and dynamics are coming of age

Keda Zhou et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Review Chemistry, Multidisciplinary

Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation

Huan-Xiang Zhou et al.

CHEMICAL REVIEWS (2018)

Article Biochemistry & Molecular Biology

Regulation of Nucleosome Stacking and Chromatin Compaction by the Histone H4 N-Terminal Tail-H2A Acidic Patch Interaction

Qinming Chen et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Article Multidisciplinary Sciences

Structural basis for spumavirus GAG tethering to chromatin

Paul Lesbats et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Virology

Foamy virus zoonotic infections

Delia M. Pinto-Santini et al.

RETROVIROLOGY (2017)

Review Biochemistry & Molecular Biology

Chromatin deregulation in disease

Anne C. Mirabella et al.

CHROMOSOMA (2016)

Review Chemistry, Multidisciplinary

Retroviral DNA Integration

Paul Lesbats et al.

CHEMICAL REVIEWS (2016)

Article Virology

Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12

Jonathon D. Brzezinski et al.

JOURNAL OF VIROLOGY (2016)

Article Virology

Phosphorylation Requirement of Murine Leukemia Virus p12

Jonathon D. Brzezinski et al.

JOURNAL OF VIROLOGY (2016)

Article Multidisciplinary Sciences

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Gregory A. Sowd et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Structural basis for retroviral integration into nucleosomes

Daniel P. Maskell et al.

NATURE (2015)

Review Microbiology

Nuclear entry of DNA viruses

Nikta Fay et al.

FRONTIERS IN MICROBIOLOGY (2015)

Review Chemistry, Multidisciplinary

Nucleosome Structure and Function

Robert K. McGinty et al.

CHEMICAL REVIEWS (2015)

Article Multidisciplinary Sciences

Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence

Qiming Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag

William M. Schneider et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

HIV Gag polyprotein: processing and early viral particle assembly

Neil M. Bell et al.

TRENDS IN MICROBIOLOGY (2013)

Review Virology

The Foamy Virus Gag Proteins: What Makes Them Different?

Erik Mullers

VIRUSES-BASEL (2013)

Review Virology

Evolution of Foamy Viruses: The Most Ancient of All Retroviruses

Axel Rethwilm et al.

VIRUSES-BASEL (2013)

Review Virology

Murine Leukemia Viruses: Objects and Organisms

Alan Rein

ADVANCES IN VIROLOGY (2011)

Review Biochemistry & Molecular Biology

Chromosomal tethering and proviral integration

Olivier Delelis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2010)

Article Biochemistry & Molecular Biology

Role of Direct Interactions between the Histone H4 Tail and the H2A Core in Long Range Nucleosome Contacts

Divya Sinha et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket

Lucie Roussel et al.

EMBO REPORTS (2008)

Article Cell Biology

Chromatin tethering of incoming foamy virus by the structural Gag protein

Joelle Tobaly-Tapiero et al.

TRAFFIC (2008)

Article Biochemistry & Molecular Biology

A charged and contoured surface on the nucleosome regulates chromatin compaction

Jayanth V. Chodaparambil et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA

AJ Barbera et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation

M Nevels et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Biochemistry & Molecular Biology

Chromatin dynamics at DNA replication, transcription and repair

AE Ehrenhofer-Murray

EUROPEAN JOURNAL OF BIOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Chromatin fiber folding: Requirement for the histone H4N-terminal tail

B Dorigo et al.

JOURNAL OF MOLECULAR BIOLOGY (2003)