期刊
JOURNAL OF FUNCTIONAL FOODS
卷 92, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2022.105022
关键词
Anti-obesity; High-fat diet; Sargassum horneri; Mitochondrial uncoupling protein
资金
- National Research Foundation of Korea (NRF) through the Ministry of Education [2018R1C1B6004780, 2020R1A2C2102697]
- Main Research Program of the Korea Food Research Institute (KFRI) - Ministry of Science and ICT [E0211200-02]
- National Research Council of Science & Technology (NST), Republic of Korea [E0211200-02] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2018R1C1B6004780, 2020R1A2C2102697] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study found that the ethanol extract of Sargassum horneri (SH) can reduce body weight and fat accumulation in high-fat diet-induced obese mice, and positively affect the expression of mitochondrial uncoupling protein 1 and mitochondrial uncoupling protein 3 in brown adipose tissue. Additionally, serum triglyceride, cholesterol, and leptin levels were significantly decreased in mice administered SH.
Obesity is a serious health problem worldwide and can lead to the development of metabolic syndromes, including hypertension, type 2 diabetes, and hyperglycemia. Therefore, we investigated the effect of an ethanol extract of Sargassum horneri (SH) on high-fat diet (HFD)-induced obese mice. To determine whether SH has an anti-obesity effect, C57BL/6 mice fed with HFD containing SH (100 and 300 mg/kg) were investigated for 7 weeks. The administration of SH significantly reduced body weight, white adipose tissue weight, fat accumulation in the liver, and white adipose tissues by increasing the mRNA expression of mitochondrial uncoupling protein 1 and mitochondrial uncoupling protein 3 in brown adipose tissues. Additionally, serum triglyceride, cholesterol, and leptin levels were significantly decreased in the mice administered SH compared with those of the HFD group. Our results showed that the ethanol extract of SH may be used as a functional food for treating obesity.
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