期刊
JOURNAL OF FUNCTIONAL FOODS
卷 90, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2022.104969
关键词
Kimchi; Companilactobacillus allii WiKim39; Lactococcus lactis WiKim0124; Vegetable juice fermentation; Anti-inflammation
资金
- Ministry of Small and Medium-sized Enterprises (SMEs) [1425147903]
- Ministry of Science and ICT, Republic of Korea [KE2102-1, KE2202-1]
- National Research Council of Science & Technology (NST), Republic of Korea [KE2202-1, KE2102-1] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Lactic acid bacteria isolated from kimchi have beneficial effects such as antioxidant, anti-obesity, anti-cancer, and immunomodulatory effects. The fermented vegetable juice showed immunomodulatory effects in vitro and in vivo, indicating its potential use in health promoting fermented foods.
Lactic acid bacteria (LAB) isolated from kimchi has beneficial antioxidant, anti-obesity, anti-cancer and immunomodulatory effects. Here, we investigated the immunomodulatory effects of vegetable juice (VJ) fermented with Companilactobacillus allii WiKim39 (VJ + WiKim39) or Lactococcus lactis WiKim0124 (VJ + WiKim0124) isolated from kimchi, in vitro and in vivo. Nitric oxide (NO) production and levels of inflammatory markers were significantly lower in lipopolysaccharide (LPS)-stimulated RAW264.7 cells treated with heat-inactivated VJ + WiKim39 and heat-inactivated VJ + WiKim0124 than in untreated cells (P < 0.05). In mice with dextran sulfate sodium (DSS)-induced colitis, oral administration of VJ + WiKim39 and VJ + WiKim0124 attenuated DSSinduced decrease in colon length and mucosal epithelia. Moreover, VJ + WiKim39 and VJ + WiKim0124 significantly downregulated several inflammatory markers (P < 0.05). Overall, WiKim39 and WiKim0124 showed immunomodulatory activity in vitro and in vivo and thus, they could be used in health promoting fermented foods.
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