期刊
ONCOTARGETS AND THERAPY
卷 15, 期 -, 页码 277-290出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S329262
关键词
tissue transglutaminase; glioblastoma; anti-cancer drugs; review
资金
- National Cancer Institute [5R01CA201402-07]
Tissue transglutaminase (tTG) is a unique enzyme that plays important roles in cellular processes and cancer progression, especially in glioblastoma. This review provides an overview of the transglutaminase family, discusses the biochemical activities of tTG, and considers current approaches to target tTG.
Tissue transglutaminase (tTG) is a rather unique GTP-binding/protein crosslinking enzyme that has been shown to play important roles in a number of cellular processes that impact both normal physiology and disease states. This is especially the case in the context of aggressive brain tumors, such as glioblastoma. The diverse roles played by tTG in cancer survival and progression have led to significant interest in recent years in using tTG as a therapeutic target. In this review, we provide a brief overview of the transglutaminase family, and then discuss the primary biochemical activities exhibited by tTG with an emphasis on the role it plays in glioblastoma progression. Finally, we consider current approaches to target tTG which might eventually have clinical impact.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据