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The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Summary: This study demonstrated that long non-coding RNA TCTN2 exerts its effects in spinal cord injury (SCI) through mesenchymal stem cells (MSCs)-derived exosomes, improving functional recovery and reducing neuronal apoptosis, inflammation, and oxidative stress. The findings suggest a potential novel therapy for SCI utilizing MSC-exosomes modified with TCTN2 to target the miR-329-3p/IGF1R axis.

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Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-κB signaling pathway

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Shaowei Guo et al.

ACS NANO (2019)

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Article Cell & Tissue Engineering

Exosomes from Bone Marrow Mesenchymal Stem Cells Inhibit Neuronal Apoptosis and Promote Motor Function Recovery via the Wnt/β-catenin Signaling Pathway

Ci Li et al.

CELL TRANSPLANTATION (2019)

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Article Medicine, Research & Experimental

Highlight article: Identification of serum exosomal microRNAs in acute spinal cord injured rats

Shu-Qin Ding et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

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Article Biochemistry & Molecular Biology

MiR-21 derived from the exosomes of MSCs regulates the death and differentiation of neurons in patients with spinal cord injury

Jian Kang et al.

GENE THERAPY (2019)

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Review Cell & Tissue Engineering

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

Anwen Shao et al.

STEM CELL RESEARCH & THERAPY (2019)

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Review Multidisciplinary Sciences

Moving beyond the glial scar for spinal cord repair

Elizabeth J. Bradbury et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Medicinal

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury

Chuanliang Zhao et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

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Article Cell Biology

Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism

Ke Ma et al.

AGING-US (2019)

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Article Biochemistry & Molecular Biology

miR-21 deficiency contributes to the impaired protective effects of obese rat mesenchymal stem cell-derived exosomes against spinal cord injury

Wenchen Ji et al.

BIOCHIMIE (2019)

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Article Cell Biology

miR-21 and miR-19b delivered by hMSC-derived EVs regulate the apoptosis and differentiation of neurons in patients with spinal cord injury

Guanghui Xu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Clinical Neurology

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

Robin L. Webb et al.

TRANSLATIONAL STROKE RESEARCH (2018)

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Review Cell Biology

The emerging role of long non-coding RNA in spinal cord injury

Zhongju Shi et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Materials Science, Biomaterials

hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation

Guodong Sun et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Chemistry, Multidisciplinary

Therapeutic Efficacy-Potentiated and Diseased Organ-Targeting Nanovesicles Derived from Mesenchymal Stem Cells for Spinal Cord Injury Treatment

Han Young Kim et al.

NANO LETTERS (2018)

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Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Multidisciplinary Sciences

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

Karen L. Lankford et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

Themistoklis M. Tsarouchas et al.

NATURE COMMUNICATIONS (2018)

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Article Neurosciences

Exosomes Derived From miR-133b-Modified Mesenchymal Stem Cells Promote Recovery After Spinal Cord Injury

Dong Li et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Review Medicine, General & Internal

Neural stem cell derived extracellular vesicles: Attributes and prospects for treating neurodegenerative disorders

Andrew Vogel et al.

EBIOMEDICINE (2018)

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Review Pharmacology & Pharmacy

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Sophia G. Antimisiaris et al.

PHARMACEUTICS (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell Biology

Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NF kappa B P65 Subunit in Spinal Cord Injury

Lin Wang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Current knowledge on exosome biogenesis and release

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Article Neurosciences

Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury

Hemant Kumar et al.

MOLECULAR NEUROBIOLOGY (2017)

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Article Critical Care Medicine

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats

Jiang-Hu Huang et al.

JOURNAL OF NEUROTRAUMA (2017)

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Article Biochemistry & Molecular Biology

Non-coding RNAs and neuroprotection after acute CNS injuries

Raghavendar Chandran et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

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Article Cell & Tissue Engineering

Stem Cell-Derived Extracellular Vesicles as a Novel Potential Therapeutic Tool for Tissue Repair

Bi Chen et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Medicine, General & Internal

Traumatic spinal cord injury

Christopher S. Ahuja et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Review Neurosciences

Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration

Songlin Zhou et al.

NEUROSCIENCE BULLETIN (2016)

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Article Cell Biology

Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

Chris Gardiner et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Review Biochemistry & Molecular Biology

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Hina Kalra et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Surgery

Micro ARN y su papel en la fisiopatología de la lesión medular; un paso más hacia la medicina neurorregenerativa

Jimena Quinzaños-Fresnedo et al.

Cirugia y Cirujanos (2015)

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Article Chemistry, Multidisciplinary

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

Tyson Smyth et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Using exosomes, naturally-equipped nanocarriers, for drug delivery

Elena V. Batrakova et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Multidisciplinary Sciences

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sonia A. Melo et al.

NATURE (2015)

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Article Clinical Neurology

Pharmacological Therapy for Acute Spinal Cord Injury

R. John Hurlbert et al.

NEUROSURGERY (2015)

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Review Neurosciences

The regulatory roles of non-coding RNAs in nerve injury and regeneration

Bin Yu et al.

PROGRESS IN NEUROBIOLOGY (2015)

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Article Cell & Tissue Engineering

Concise Review: Reactive Astrocytes and Stem Cells in Spinal Cord Injury: Good Guys or Bad Guys?

Dunja Lukovic et al.

STEM CELLS (2015)

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Review Oncology

The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications

Yukie Sato-Kuwabara et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Letter Cell Biology

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

Caitlin Williams et al.

CELL RESEARCH (2014)

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Review Clinical Neurology

Physical therapy after spinal cord injury: A systematic review of treatments focused on participation

Natalia Gomara-Toldra et al.

JOURNAL OF SPINAL CORD MEDICINE (2014)

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Review Biotechnology & Applied Microbiology

Exosomes for drug delivery - a novel application for the mesenchymal stem cell

Ruenn Chai Lai et al.

BIOTECHNOLOGY ADVANCES (2013)

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Review Clinical Neurology

The emerging roles of microRNAs in CNS injuries

Oneil G. Bhalala et al.

NATURE REVIEWS NEUROLOGY (2013)

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Article Clinical Neurology

The Acute Cardiopulmonary Management of Patients With Cervical Spinal Cord Injuries

Timothy C. Ryken et al.

NEUROSURGERY (2013)

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Article Multidisciplinary Sciences

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

Takeshi Katsuda et al.

SCIENTIFIC REPORTS (2013)

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Article Clinical Neurology

Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury

Jee Y. Lee et al.

BRAIN (2012)

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Review Clinical Neurology

Evaluation of clinical experience using cell-based therapies in patients with spinal cord injury: a systematic review

James S. Harrop et al.

JOURNAL OF NEUROSURGERY-SPINE (2012)

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Review Multidisciplinary Sciences

Epigenetic Regulation by Long Noncoding RNAs

Jeannie T. Lee

SCIENCE (2012)

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Review Oncology

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

Nobuyoshi Kosaka et al.

CANCER SCIENCE (2010)

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Article Biochemistry & Molecular Biology

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

Isabella Parolini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Review Genetics & Heredity

Long non-coding RNAs: insights into functions

Tim R. Mercer et al.

NATURE REVIEWS GENETICS (2009)

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Review Neurosciences

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

Dustin J. Donnelly et al.

EXPERIMENTAL NEUROLOGY (2008)

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Review Biochemistry & Molecular Biology

Noncoding RNA in development

Paulo P. Amaral et al.

MAMMALIAN GENOME (2008)

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Review Clinical Neurology

Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

James W. Rowland et al.

NEUROSURGICAL FOCUS (2008)

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Review Neurosciences

Regeneration beyond the glial scar

J Silver et al.

NATURE REVIEWS NEUROSCIENCE (2004)

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Article Neurosciences

Deconstructing the axon: Wallerian degeneration and the ubiquitin-proteasome system

MD Ehlers

TRENDS IN NEUROSCIENCES (2004)

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Article Neurosciences

Blood-spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing

WD Whetstone et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

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Review Immunology

Exosomes:: Composition, biogenesis and function

C Théry et al.

NATURE REVIEWS IMMUNOLOGY (2002)

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Review Medicine, General & Internal

Spinal-cord injury

JW McDonald et al.

LANCET (2002)

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Article Biochemistry & Molecular Biology

Non-coding RNAs: the architects of eukaryotic complexity

JS Mattick

EMBO REPORTS (2001)

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