期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 16, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2022.838007
关键词
EGF; EGFR; ErbB; oligodendrocyte; myelin; aging; white matter
资金
- Biotechnology and Biological Sciences Research Council (BBSRC, UK) [BB/M029379/1]
- Medical Research Council (MRC, UK) [MR/P025811/1]
- MSCA Seal of Excellence @ UNIPD
- NVIDIA Hardware Grant
- German Research Council [AZ/115/1-1, AZ/115/1-3]
- Swiss National Funds [P300PA_171224]
This review discusses the importance of Epidermal Growth Factor (EGF) signaling in regulating biological pathways in oligodendroglia during aging, impacting the regenerative capacity of OPCs, as well as the loss and regeneration of myelin in age-related pathologies such as AD and MS.
Oligodendrocytes (OLs) are specialized glial cells that myelinate CNS axons. OLs are generated throughout life from oligodendrocyte progenitor cells (OPCs) via a series of tightly controlled differentiation steps. Life-long myelination is essential for learning and to replace myelin lost in age-related pathologies such as Alzheimer's disease (AD) as well as white matter pathologies such as multiple sclerosis (MS). Notably, there is considerable myelin loss in the aging brain, which is accelerated in AD and underpins the failure of remyelination in secondary progressive MS. An important factor in age-related myelin loss is a marked decrease in the regenerative capacity of OPCs. In this review, we will contextualize recent advances in the key role of Epidermal Growth Factor (EGF) signaling in regulating multiple biological pathways in oligodendroglia that are dysregulated in aging.
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