相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Early Appearance of Dendritic Alterations in Neocortical Pyramidal Neurons of the Ts65Dn Model of Down Syndrome
Beatrice Uguagliati et al.
DEVELOPMENTAL NEUROSCIENCE (2022)
Early postnatal oleic acid administration enhances synaptic development and cognitive abilities in the Ts65Dn mouse model of Down syndrome
Veronica Vidal et al.
NUTRITIONAL NEUROSCIENCE (2022)
Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin
Takahiro Masaki et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Impaired Brain Mitochondrial Bioenergetics in the Ts65Dn Mouse Model of Down Syndrome Is Restored by Neonatal Treatment with the Polyphenol 7,8-Dihydroxyflavone
Daniela Valenti et al.
ANTIOXIDANTS (2022)
Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
Alberto Granato et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)
Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model
Xu-Qiao Chen et al.
ALZHEIMERS & DEMENTIA (2021)
Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome
Hyuk Jin Yun et al.
CEREBRAL CORTEX (2021)
Intellectual disability: dendritic anomalies and emerging genetic perspectives
Tam T. Quach et al.
ACTA NEUROPATHOLOGICA (2021)
Early appearance of developmental alterations in the dendritic tree of the hippocampal granule cells in the Ts65Dn model of Down syndrome
Beatrice Uguagliati et al.
HIPPOCAMPUS (2021)
Maternal Choline Supplementation as a Potential Therapy for Down Syndrome: Assessment of Effects Throughout the Lifespan
Brian E. Powers et al.
FRONTIERS IN AGING NEUROSCIENCE (2021)
Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome
Helin Atas-Ozcan et al.
GENES (2021)
C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage?
Laura Reiche et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
The flavonoid 7,8-DHF fosters prenatal brain proliferation potency in a mouse model of Down syndrome
Fiorenza Stagni et al.
SCIENTIFIC REPORTS (2021)
Growing Glia: Cultivating Human Stem Cell Models of Gliogenesis in Health and Disease
Samantha N. Lanjewar et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Criss-crossing autism spectrum disorder and adult neurogenesis
Frank Bicker et al.
JOURNAL OF NEUROCHEMISTRY (2021)
Identification of neural oscillations and epileptiform changes in human brain organoids
Ranmal A. Samarasinghe et al.
NATURE NEUROSCIENCE (2021)
Astrocytes in Down Syndrome Across the Lifespan
Blandine Ponroy Bally et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model
Jesus David Urbano-Gamez et al.
MOLECULAR BRAIN (2021)
DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome
Xiao-Yan Tang et al.
JOURNAL OF CLINICAL INVESTIGATION (2021)
Quantitative MRI Analyses of Regional Brain Growth in Living Fetuses with Down Syndrome
Tomo Tarui et al.
CEREBRAL CORTEX (2020)
A comprehensive examination of the memory profile of youth with Down syndrome in comparison to typically developing peers
Mary Godfrey et al.
CHILD NEUROPSYCHOLOGY (2020)
Down syndrome
Stylianos E. Antonarakis et al.
NATURE REVIEWS DISEASE PRIMERS (2020)
Prenatal Administration of Oleic Acid or Linolenic Acid Reduces Neuromorphological and Cognitive Alterations in Ts65dn Down Syndrome Mice
Susana Garcia-Cerro et al.
JOURNAL OF NUTRITION (2020)
Birth incidence, deaths and hospitalisations of children and young people with Down syndrome, 1990-2015: birth cohort study
Laura Anne Hughes-McCormack et al.
BMJ OPEN (2020)
Neuroanatomical alterations in higher-order thalamic nuclei of fetuses with Down syndrome
Fiorenza Stagni et al.
CLINICAL NEUROLOGY AND NEUROSURGERY (2020)
Prenatal, but not Postnatal, Curcumin Administration Rescues Neuromorphological and Cognitive Alterations in Ts65Dn Down Syndrome Mice
Noemi Rueda et al.
JOURNAL OF NUTRITION (2020)
Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model
Faycal Guedj et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2020)
Amyloid precursor protein intracellular domain-dependent regulation of FOXO3a inhibits adult hippocampal neurogenesis
Mei Jiang et al.
NEUROBIOLOGY OF AGING (2020)
Neonatal therapy with clenbuterol and salmeterol restores spinogenesis and dendritic complexity in the dentate gyrus of the Ts65Dn model of Down syndrome
Marco Emili et al.
NEUROBIOLOGY OF DISEASE (2020)
Down Syndrome
Marilyn J. Bull
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Brain organoids: Human 3D models to investigate neuronal circuits assembly, function and dysfunction
M. Tambalo et al.
BRAIN RESEARCH (2020)
Early alterations in cortical and cerebellar regional brain growth in Down Syndrome: An in vivo fetal and neonatal MRI assessment
Prachi A. Patkee et al.
NEUROIMAGE-CLINICAL (2020)
Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation
Sonja M. Sachse et al.
EMBO JOURNAL (2019)
Dementia in Down syndrome: unique insights for Alzheimer disease research
Ira T. Lott et al.
NATURE REVIEWS NEUROLOGY (2019)
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome
Ranjie Xu et al.
CELL STEM CELL (2019)
New approaches to studying early brain development in Down syndrome
Ana A. Baburamani et al.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2019)
Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions
Maria Sobol et al.
MOLECULAR NEUROBIOLOGY (2019)
Neonatal treatment with cyclosporine A restores neurogenesis and spinogenesis in the Ts65Dn model of Down syndrome
Fiorenza Stagni et al.
NEUROBIOLOGY OF DISEASE (2019)
Calcineurin regulates cyclin D1 stability through dephosphorylation at T286
Takahiro Goshima et al.
SCIENTIFIC REPORTS (2019)
Subicular hypotrophy in fetuses with Down syndrome and in the Ts65Dn model of Down syndrome
Fiorenza Stagni et al.
BRAIN PATHOLOGY (2019)
Neural histology and neurogenesis of the human fetal and infant brain
I. Kostovic et al.
NEUROIMAGE (2019)
Down syndrome: Neurobiological alterations and therapeutic targets
Rosa Anna Vacca et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2019)
Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models
Benoit Souchet et al.
SCIENTIFIC REPORTS (2019)
Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved
Raquel Coronel et al.
NEURAL REGENERATION RESEARCH (2019)
Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome
Wen-Bo Zhou et al.
NEURAL REGENERATION RESEARCH (2019)
Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse
Andrea Giacomini et al.
ANTIOXIDANTS (2019)
Abnormal development of the inferior temporal region in fetuses with Down syndrome
Sandra Guidi et al.
BRAIN PATHOLOGY (2018)
A highlight on Sonic hedgehog pathway
Gabriela Basile Carballo et al.
CELL COMMUNICATION AND SIGNALING (2018)
Neurogenesis impairment: An early developmental defect in Down syndrome
Fiorenza Stagni et al.
FREE RADICAL BIOLOGY AND MEDICINE (2018)
A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS
Fiorenza Stagni et al.
EXPERIMENTAL NEUROLOGY (2017)
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature
Thu Lan Nguyen et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2017)
Local translation of the Down syndrome cell adhesion molecule (DSCAM) mRNA in the vertebrate central nervous system
Maria Luz Montesinos
JOURNAL OF NEUROGENETICS (2017)
Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome
Fiorenza Stagni et al.
NEUROBIOLOGY OF DISEASE (2017)
Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes
Megan Stringer et al.
PHYSIOLOGY & BEHAVIOR (2017)
Fetal therapy for Down syndrome: an ethical exploration
Guido de Wert et al.
PRENATAL DIAGNOSIS (2017)
Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice
Akiko Nakano-Kobayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice
Xiaomin Yin et al.
SCIENTIFIC REPORTS (2017)
Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer's-like memory deficits in the Ts65Dn mouse model of Down syndrome
Syed Faraz Kazim et al.
SCIENTIFIC REPORTS (2017)
Pharmacological interventions to improve cognition and adaptive functioning in Down syndrome: Strides to date
Sarah J. Hart et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2017)
Pre-and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome
Andrea Corrales et al.
BEHAVIOURAL BRAIN RESEARCH (2017)
Neural stem cells and neuro/gliogenesis in the central nervous system: understanding the structural and functional plasticity of the developing, mature, and diseased brain
Masahiro Yamaguchi et al.
JOURNAL OF PHYSIOLOGICAL SCIENCES (2016)
Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease
S. Kim et al.
MOLECULAR PSYCHIATRY (2016)
Epigenetic dysregulation in the developing Down syndrome cortex
Nady El Hajj et al.
EPIGENETICS (2016)
Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination
Jose Luis Olmos-Serrano et al.
NEURON (2016)
SHORT- AND LONG-TERM EFFECTS OF NEONATAL PHARMACOTHERAPY WITH EPIGALLOCATECHIN-3-GALLATE ON HIPPOCAMPAL DEVELOPMENT IN THE Ts65Dn MOUSE MODEL OF DOWN SYNDROME
Fiorenza Stagni et al.
NEUROSCIENCE (2016)
Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension
Ramon Perez-Nunez et al.
NEUROTOXICITY RESEARCH (2016)
Regulation of global gene expression and cell proliferation by APP
Yili Wu et al.
SCIENTIFIC REPORTS (2016)
Trisomy 21 consistently activates the interferon response
Kelly D. Sullivan et al.
ELIFE (2016)
Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain
Han-Chung Lee et al.
NEURAL PLASTICITY (2016)
The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome
Shan Shan Li et al.
SCIENTIFIC REPORTS (2016)
DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex
Lei Zhang et al.
BRAIN RESEARCH (2015)
DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model
Nobuhiro Kurabayashi et al.
EMBO REPORTS (2015)
NFAT Transcription Factors Regulate Survival, Proliferation, Migration, and Differentiation of Neural Precursor Cells
Maria C. Serrano-Perez et al.
GLIA (2015)
Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome
Andrea Giacomini et al.
NEUROBIOLOGY OF DISEASE (2015)
Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice
Fiorenza Stagni et al.
NEUROBIOLOGY OF DISEASE (2015)
Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region
Wei Liu et al.
NEUROBIOLOGY OF DISEASE (2015)
Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model
Megan Stringer et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2015)
Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration
Aoife Murray et al.
STEM CELLS (2015)
APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation
R. Shu et al.
CELL DEATH & DISEASE (2015)
Timing of therapies for Down syndrome: the sooner, the better
Fiorenza Stagni et al.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2015)
DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome
Sonia Najas et al.
EBIOMEDICINE (2015)
Altered Distribution of Hippocampal Interneurons in the Murine Down Syndrome Model Ts65Dn
Samuel Hernandez-Gonzalez et al.
NEUROCHEMICAL RESEARCH (2015)
Formoterol, a Long-Acting β2 Adrenergic Agonist, Improves Cognitive Function and Promotes Dendritic Complexity in a Mouse Model of Down Syndrome
Van Dang et al.
BIOLOGICAL PSYCHIATRY (2014)
Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model
Sandra Guidi et al.
BRAIN (2014)
The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation
Ulf Soppa et al.
CELL CYCLE (2014)
Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21
Youssef Hibaoui et al.
EMBO MOLECULAR MEDICINE (2014)
Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice
Christy M. Kelley et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2014)
Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
Rafael De la Torre et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2014)
APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome
Stefania Trazzi et al.
NEUROBIOLOGY OF DISEASE (2014)
Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells
Chen Chen et al.
NATURE COMMUNICATIONS (2014)
Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations
Katheleen J. Gardiner
DRUG DESIGN DEVELOPMENT AND THERAPY (2014)
Somal and Dendritic Development of Human CA3 Pyramidal Neurons From Midgestation to Middle Childhood: A Quantitative Golgi Study
Dahua Lu et al.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2013)
Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-κB in the pathogenesis of Down syndrome
Barbara Granese et al.
BMC MEDICAL GENOMICS (2013)
Early Pharmacotherapy with Fluoxetine Rescues Dendritic Pathology in the Ts65Dn Mouse Model of Down Syndrome
Sandra Guidi et al.
BRAIN PATHOLOGY (2013)
Dynamics of Hippocampal Neurogenesis in Adult Humans
Kirsty L. Spalding et al.
CELL (2013)
Prospects for Improving Brain Function in Individuals with Down Syndrome
Alberto C. S. Costa et al.
CNS DRUGS (2013)
Atypical aging in down syndrome
Warren B. Zigman
Developmental Disabilities Research Reviews (2013)
Modeling neurogenesis impairment in down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells
Huai-En Lu et al.
EXPERIMENTAL CELL RESEARCH (2013)
The amyloid precursor protein: A biochemical enigma in brain development, function and disease
Natalia N. Nalivaeva et al.
FEBS LETTERS (2013)
Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells
Nobuhiro Kurabayashi et al.
GENES & DEVELOPMENT (2013)
Noninvasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012
E. Mersy et al.
HUMAN REPRODUCTION UPDATE (2013)
Inhibition of GSK3 beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes
Philip T. T. Ly et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Size Does Not Always Matter: Ts65Dn Down Syndrome Mice Show Cerebellum-Dependent Motor Learning Deficits that Cannot Be Rescued by Postnatal SAG Treatment
Nicolas Gutierrez-Castellanos et al.
JOURNAL OF NEUROSCIENCE (2013)
Neurogenesis Continues in the Third Trimester of Pregnancy and Is Suppressed by Premature Birth
Sabrina Malik et al.
JOURNAL OF NEUROSCIENCE (2013)
Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle
Jia-Yun Chen et al.
MOLECULAR CELL (2013)
Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome
Ramon Velazquez et al.
NEUROBIOLOGY OF DISEASE (2013)
Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
Anna M. Lilja et al.
PLOS ONE (2013)
Pharmacotherapy with Fluoxetine Restores Functional Connectivity from the Dentate Gyrus to Field CA3 in the Ts65Dn Mouse Model of Down Syndrome
Fiorenza Stagni et al.
PLOS ONE (2013)
Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model
Ishita Das et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology
James A. Briggs et al.
STEM CELLS (2013)
Co-ordination of cell cycle and differentiation in the developing nervous system
Christopher Hindley et al.
BIOCHEMICAL JOURNAL (2012)
OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors
Jie Lu et al.
HUMAN MOLECULAR GENETICS (2012)
Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory
Katherine R. Martin et al.
HUMAN MOLECULAR GENETICS (2012)
Impaired myelination of the human hippocampal formation in Down syndrome
Hajnalka Abraham et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2012)
Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice
Bozena Mazur-Kolecka et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2012)
Local generation of glia is a major astrocyte source in postnatal cortex
Woo-Ping Ge et al.
NATURE (2012)
MicroRNAs and Fetal Brain Development: Implications for Ethanol Teratology during the Second Trimester Period of Neurogenesis
Rajesh C. Miranda
Frontiers in Genetics (2012)
Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome
Sandra Guidi et al.
BRAIN PATHOLOGY (2011)
Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling
Barbara Haemmerle et al.
DEVELOPMENT (2011)
SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalon
Scott R. Hutton et al.
DEVELOPMENTAL BIOLOGY (2011)
MNB/DYRK1A as a multiple regulator of neuronal development
Francisco J. Tejedor et al.
FEBS JOURNAL (2011)
α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome
Mototada Shichiri et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome
Stefania Trazzi et al.
HUMAN MOLECULAR GENETICS (2011)
Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated Phosphorylation
Min-Su Jung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Prevention of Learning Deficit in a Down Syndrome Model
Maddalena Incerti et al.
OBSTETRICS AND GYNECOLOGY (2011)
Ascl1/Mash1 Is a Novel Target of Gli2 during Gli2-Induced Neurogenesis in P19 EC Cells
Anastassia Voronova et al.
PLOS ONE (2011)
S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors
Jie Lu et al.
PLOS ONE (2011)
Functions of GSK-3 signaling in development of the nervous system
Woo-Yang Kim et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)
The development of the subplate and thalamocortical connections in the human foetal brain
Ivica Kostovic et al.
ACTA PAEDIATRICA (2010)
Perinatal Choline Supplementation Improves Cognitive Functioning and Emotion Regulation in the Ts65Dn Mouse Model of Down Syndrome
Jisook Moon et al.
BEHAVIORAL NEUROSCIENCE (2010)
Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells
Joongkyu Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway
Nikolai D. Belyaev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome
D. Perez-Cremades et al.
JOURNAL OF NEURAL TRANSMISSION (2010)
Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells
Odessa Yabut et al.
JOURNAL OF NEUROSCIENCE (2010)
Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome
Patrizia Bianchi et al.
JOURNAL OF NEUROSCIENCE (2010)
Developmental genetics of vertebrate glial-cell specification
David H. Rowitch et al.
NATURE (2010)
Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
Lina Chakrabarti et al.
NATURE NEUROSCIENCE (2010)
The Basics of Brain Development
Joan Stiles et al.
NEUROPSYCHOLOGY REVIEW (2010)
Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome
Andrea Contestabile et al.
BRAIN PATHOLOGY (2009)
Evolution of the neocortex: a perspective from developmental biology
Pasko Rakic
NATURE REVIEWS NEUROSCIENCE (2009)
Antidepressants increase neural progenitor cells in the human hippocampus
Maura Boldrini et al.
NEUROPSYCHOPHARMACOLOGY (2009)
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome
Claudia Canzonetta et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Reduced cell number in the neocortical part of the human fetal brain in Down syndrome
Karen Bonde Larsen et al.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2008)
Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome
Noemi Rueda et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
GSK-3 beta regulates cyclin D1 expression: A new target for chemotherapy
Fumi Takahashi-Yanaga et al.
CELLULAR SIGNALLING (2008)
Neurite arborization and mosaic spacing in the mouse retina require DSCAM
Peter G. Fuerst et al.
NATURE (2008)
Development of the human cerebral cortex: Boulder Committee revisited
Irina Bystron et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Prevention of Developmental Delays in a Down Syndrome Mouse Model
Laura Toso et al.
OBSTETRICS AND GYNECOLOGY (2008)
Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome
Sandra Guidi et al.
BRAIN PATHOLOGY (2008)
Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury
Giuseppe Esposito et al.
HUMAN MOLECULAR GENETICS (2008)
A molecular neuroanatomical study of the developing human neocortex from 8 to 17 postconceptional weeks revealing the early differentiation of the subplate and subventricular zone
Nadhim Bayatti et al.
CEREBRAL CORTEX (2008)
Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers
Anamaria Sudarov et al.
NEURAL DEVELOPMENT (2007)
Defects in embryonic Neurogenesis and initial synapse formation in the Forebrain of the Ts65Dn mouse model of down syndrome
Lina Chakrabarti et al.
JOURNAL OF NEUROSCIENCE (2007)
Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype-phenotype relationships
Pavel V. Belichenko et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2007)
ERK implication in cell cycle regulation
Jean-Claude Chambard et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome
Wieslaw K. Dowjat et al.
NEUROSCIENCE LETTERS (2007)
Specific transcriptional changes in human fetuses with autosomal trisomies
O. Altug-Teber et al.
CYTOGENETIC AND GENOME RESEARCH (2007)
Alzheimer's disease in Down syndrome: Neurobiology and risk
Warren B. Zigman et al.
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS (2007)
Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with down syndrome and in Ts65Dn mice
Andrea Contestabile et al.
HIPPOCAMPUS (2007)
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
Joseph R. Arron et al.
NATURE (2006)
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity
J Cayuso et al.
DEVELOPMENT (2006)
Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice
RJ Roper et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Altered organization of cortical interneurons in rats exposed to ethanol during neonatal life
A Granato
BRAIN RESEARCH (2006)
Biometry of face and brain in fetuses with trisomy 21
AM Guihard-Costa et al.
PEDIATRIC RESEARCH (2006)
Dendritic pathology in mental retardation: from molecular genetics to neurobiology
M Dierssen et al.
GENES BRAIN AND BEHAVIOR (2006)
Development of interlaminar astroglial processes in the cerebral cortex of control and Down's syndrome human cases
JA Colombo et al.
EXPERIMENTAL NEUROLOGY (2005)
Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation
T Setoguchi et al.
JOURNAL OF CELL BIOLOGY (2004)
Synaptic structural abnormalities in the Ts65Dn mouse model of Down syndrome
PV Belichenko et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2004)
On dendrties in Down syndrome and DS murine models:: a spiny way to learn
R Benavides-Piccione et al.
PROGRESS IN NEUROBIOLOGY (2004)
Development and developmental disorders of the human cerebellum
HJ ten Donkelaar et al.
JOURNAL OF NEUROLOGY (2003)
Developmental and evolutionary adaptations of cortical radial glia
P Rakic
CEREBRAL CORTEX (2003)
Molecular changes in fetal Down syndrome brain
E Engidawork et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain: Challenging the gene dosage effect hypothesis (Part II)
MS Cheon et al.
AMINO ACIDS (2003)
Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain: Challenging the gene dosage effect hypothesis (Part III)
MS Cheon et al.
AMINO ACIDS (2003)
Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study
S Bahn et al.
LANCET (2002)
Patched1 interacts with cyclin B1 to regulate cell cycle progression
EA Barnes et al.
EMBO JOURNAL (2001)
Identification of amino-terminally and phosphotyrosine-modified carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain
C Russo et al.
NEUROBIOLOGY OF DISEASE (2001)
Cell formation in the human hippocampal formation from mid-gestation to the late postnatal period
L Seress et al.
NEUROSCIENCE (2001)
Translating developmental time across mammalian species
B Clancy et al.
NEUROSCIENCE (2001)
The developmental and aging changes of Down's syndrome cell adhesion molecule expression in normal and Down's syndrome brains
Y Saito et al.
ACTA NEUROPATHOLOGICA (2000)
Sonic hedgehog promotes G1 cyclin expression and sustained cell cycle progression in mammalian neuronal precursors
AM Kenney et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
JJ Fuentes et al.
HUMAN MOLECULAR GENETICS (2000)
Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models
D Rice et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2000)
分享论文
