期刊
INTERNATIONAL WOUND JOURNAL
卷 20, 期 1, 页码 120-130出版社
WILEY
DOI: 10.1111/iwj.13846
关键词
biofilm; gentian violet; Lugol's solution; MRSA; Staphylococcus aureus
This study evaluated the antibacterial efficacy of Lugol's solution and Gentian violet against MRSA biofilm in vivo, and found that these two agents effectively eradicated MRSA biofilm, suggesting their potential as alternatives or adjuncts to topical antibiotics.
The study aimed to evaluate the antibacterial efficacy of Lugol's solution 5% and Gentian violet 1% against methicillin-resistant Staphylococcus aureus (MRSA) biofilm in vivo. The bactericidal efficacy for treatment of MRSA-biofilm skin wound infection was tested in a murine model. Luciferase-tagged S. aureus Xen31, a MRSA-strain derived from S. aureus ATCC-3359130, was used for infection. Wounds were made in the skin of mice and infected with MRSA. The mice were treated with Lugol's solution and Gentian violet. Application of the antimicrobial agents started 24 hours post infection and was repeated daily for five-days. The antimicrobial effect on the biofilm bacteria was evaluated by measuring bioluminescence from MRSA daily for seven-days. Lugol's solution and Gentian violet showed a significant reduction in luminescent signals from the first assessment day to all subsequent days (P < .001). Lugol's solution and Gentian violet effectively eradicated MRSA in biofilm in vivo and could be alternatives or in addition to topical antibiotics when MRSA-biofilm wound infection is suspected.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据