Verbascoside extracted from Clerodendrum inerme: A natural monomer for the fabrication of a sensitive electrochemical Cu(II) sensor

Verbascoside is isolated from the whole plants of the Verbenaceae family and demonstrates significant levels of bioactivity. In this work, we report on the isolation of verbascoside, a phenolic glycoside, from the stems of Clerodendrum inerme collected in Vietnam and verify its structure by comparing its spectroscopic data with those reported in the literature. Verbascoside is then applied as a monomer for the electrochemical deposition of a layer of polyverbascoside onto glassy carbon electrodes toward Cu2+ sensing. Electrochemical results demonstrate that the polyverbascoside-modified glassy carbon electrode is highly selective for Cu2+ ions compared to other evaluated ions including Ni2+ and Co2+. The developed sensor can detect Cu2+ in a concentration range from 0 to 175 mu M with a sensitivity of 0.372 mu A mu M-1 and a limit of detection of 50 nM Cu2+ ions.

Automated summary

In this study, verbascoside, a phenolic glycoside, was successfully isolated from the stems of Clerodendrum inerme collected in Vietnam. It was then applied for the electrochemical sensing of Cu2+. The results showed that the polyverbascoside-modified electrode exhibited high selectivity towards Cu2+ ions and could detect them with high sensitivity.