期刊
JOURNAL OF CHEMICAL RESEARCH
卷 46, 期 2, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/17475198221088194
关键词
cyclohexanones; polycycles; radical addition; radical cyclisation; xanthates
资金
- Ecole Polytechnique
- CNRS
- DGA
- MNRT
- China Research Council
- Sanofi
- Laboratoires Servier
- Syngenta
This brief review discusses various approaches to synthesizing six-membered carbocyclic architectures using the unique radical chemistry of xanthates. These methods include modifying existing cyclohexane building blocks, combining xanthate chemistry with classical ionic reactions, and direct ring closure. The complex structures presented in this review would be challenging to obtain using traditional methods.
Convergent routes to various six-membered carbocyclic architectures exploiting the unique radical chemistry of xanthates are described in this brief review. Three approaches are discussed. The first is the modification of existing cyclohexane building blocks, namely, cyclohexanones, cyclohexenones and cyclohexenes. The second deals with the construction of six-membered carbocycles by associating the chemistry of xanthates with classical ionic reactions, especially the Robinson annulation, the Michael addition and the Horner-Wadsworth-Emmons condensation. Finally, the third route is the formation of six-membered rings by direct six-exo and, but more rarely, six-endo cyclisation modes. Many of the complex structures presented herein would be tedious to obtain by more traditional methods.
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