期刊
VIRUSES-BASEL
卷 14, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/v14030500
关键词
Puumala hantavirus; hemorrhagic fever with renal syndrome; alcohol drinking; ethanol; liver enzymes; pancreatitis; acute kidney injury
类别
资金
- Tampere University Hospital
- Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital [9AA050, 9AB046, 9AA052]
- Finnish Foundation for the Promotion of Laboratory Medicine
- Finnish Society of Clinical Chemistry
Alcohol consumption does not seem to affect the clinical course and severity of acute PUUV infection.
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. Characteristic clinical findings include acute kidney injury (AKI), thrombocytopenia, and capillary leakage. Smoking increases the risk of severe AKI, but it is not known whether alcohol consumption predisposes patients to a more severe infection. Liver and pancreatic enzymes, as well as biomarkers of alcohol consumption (gamma-glutamyl transferase, GGT; carbohydrate-deficient transferrin, CDT; GGT-CDT combination; and ethyl glucuronide, EtG), were measured from 66 patients with acute PUUV infection during hospitalization and at the convalescence phase. Alcohol consumption was present in 41% of the study population, 15% showing signs of heavy drinking. Alcohol use did not affect the severity of PUUV induced AKI nor the overall clinical picture of the infection. Liver enzyme levels (GGT or alanine aminotransferase, ALT) were elevated in 64% of the patients, but the levels did not associate with the markers reflecting the severity of the disease. Serum amylase activities at the convalescent stage were higher than those at the acute phase (p < 0.001). No cases with acute pancreatitis were found. In conclusion, our findings indicate that alcohol consumption does not seem to affect the clinical course of an acute PUUV infection.
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