期刊
CANCER LETTERS
卷 360, 期 2, 页码 89-105出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.11.051
关键词
Colorectal cancer; MicroRNA; Tumor suppressor; Oncogene
类别
资金
- National Natural Science Foundation of China [81402396]
- Yi Yao Foundation [14H0563]
Colorectal cancer (CRC) is the third most lethal malignancy, with pathogenesis intricately dependent upon microRNAs (miRNAs). miRNAs are short, non-protein coding RNAs, targeting the 3'-untranslated regions (3'-UTR) of certain mRNAs. They usually serve as tumor suppressors or oncogenes, and participate in tumor phenotype maintenance. Therefore, miRNAs consequently regulate CRC carcinogenesis and other biological functions, including apoptosis, development, angiogenesis, migration, and proliferation. Due to its differential expression and distinct stability, miRNAs are regarded as molecular biomarkers (for diagnosis/prognosis) and therapeutic targets for CRC. Recently, a remarkable number of miRNAs have been discovered with implications via incompletely understood mechanisms in CRC. As further study of relevant miRNAs continues, it is hopeful that novel miRNA-based therapeutic strategies may be available for CRC patients in the future. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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