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Manli Wang et al.
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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
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J. Grein et al.
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Peipei Song et al.
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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase
Yechun Xu et al.
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Rui Xiong et al.
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REUMATOLOGIA CLINICA (2019)
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Stefano Sainas et al.
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Priya Luthra et al.
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Anju Singh et al.
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Nam Nam Cheung et al.
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CURRENT OPINION IN BIOTECHNOLOGY (2017)
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Renata A. G. Reis et al.
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Junsheng Zhu et al.
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Shiliang Li et al.
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Yara Dadalti Fragoso et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2015)
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Vinita Sharma et al.
INTERNATIONAL JOURNAL OF MEDICINAL CHEMISTRY (2014)
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Helene Munier-Lehmann et al.
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Age-dependent dysregulation of innate immunity
Albert C. Shaw et al.
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Leflunomide for cytomegalovirus: bench to bedside
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Barry Rockx et al.
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Ian C. Davis et al.
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P Vergne-Salle et al.
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