Comparative Proteomic Analysis Reveals Mx1 Inhibits Senecavirus A Replication in PK-15 Cells by Interacting with the Capsid Proteins VP1, VP2 and VP3

Article Cell Biology

2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8

Dage Sun et al.

Summary: This study revealed the molecular mechanisms of selective autophagy in the host against viruses and demonstrated potential viral strategies to evade the autophagic process and IFN-I signaling for successful pathogenesis.

AUTOPHAGY (2022)

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Article Virology

Synergetic Contributions of Viral VP1, VP3, and 3C to Activation of the AKT-AMPK-MAPK-MTOR Signaling Pathway for Seneca Valley Virus-Induced Autophagy

Jiangwei Song et al.

Summary: This study demonstrated that Seneca Valley virus (SVV) infection activates autophagy through multiple signaling pathways, with viral proteins VP1, VP3, and 3C synergistically contributing to the activation of the AKT-AMPK-MAPK-MTOR pathway. These findings provide insight into the finely tuned molecular mechanisms of SVV-induced autophagy and may aid in the development of control strategies against SVV infection.

JOURNAL OF VIROLOGY (2022)

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Article Biochemistry & Molecular Biology

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Yasset Perez-Riverol et al.

Summary: PRIDE is the largest data repository of mass spectrometry-based proteomics data in the world, with around 500 datasets submitted per month. In addition to continuous improvements in data pipelines and infrastructure, PRIDE has developed the Spectra Archive and MAGE-TAB file format to enhance sample metadata annotation and access to mass spectra.

NUCLEIC ACIDS RESEARCH (2022)

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Article Infectious Diseases

Development of a VP2-based real-time fluorescent reverse transcription recombinase-aided amplification assay to rapidly detect Senecavirus A

Wenlong Wang et al.

Summary: In this study, a real-time fluorescent reverse transcription recombinase-aided amplification (rRT-RAA) assay was developed for the detection of Senecavirus A (SVA). The assay showed high sensitivity and specificity, comparable to the previously used PCR assay. Testing results using 189 clinical swine samples demonstrated good consistency and correlation between the rRT-RAA and rRT-PCR assays.

TRANSBOUNDARY AND EMERGING DISEASES (2022)

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Article Biochemistry & Molecular Biology

Multi-organ proteomic landscape of COVID-19 autopsies

Xiu Nie et al.

Summary: This study used proteomic analysis to reveal the molecular mechanisms of multi-organ injuries in COVID-19 patients. The data showed significant upregulation of cathepsin L1 in the lung, instead of ACE2. Systemic hyperinflammation, dysregulation of glucose and fatty acid metabolism were detected in multiple organs.

CELL (2021)

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Article Microbiology

Comparison of historical and contemporary isolates of Senecavirus A

Alexandra C. Buckley et al.

Summary: Senecavirus A (SVA) was discovered in 2002 as a cell culture contaminant, with subsequent reports of porcine idiopathic vesicular disease (PIVD) cases testing PCR positive for SVA. Experimental reproduction of disease with contemporary SVA strains raised questions about reproducing vesicular disease with historical isolates. Comparing historical and contemporary SVA isolates in growing pigs revealed differences in cross-neutralizing antibody levels, but similar clinical presentation of vesicular disease.

VETERINARY MICROBIOLOGY (2021)

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Article Cell Biology

Selective autophagy receptor SQSTM1/p62 inhibits Seneca Valley virus replication by targeting viral VP1 and VP3

Wei Wen et al.

Summary: The study explores the reciprocal regulation between the selective autophagy receptor SQSTM1 and Seneca Valley virus (SVV). Overexpression of SQSTM1 decreased viral protein production and reduced viral titers, while SVV evolved strategies to circumvent host autophagic machinery to promote viral replication. SVV's 3C(pro) targets SQSTM1 for cleavage to prevent selective autophagy and promote viral propagation.

AUTOPHAGY (2021)

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Article Genetics & Heredity

Tandem Mass Tag-Based Quantitative Proteomic Analysis of ISG15 Knockout PK15 Cells in Pseudorabies Virus Infection

Wenfeng He et al.

Summary: PRV is a significant pathogen for swine, and the identification of protein targets against PRV is crucial. The study used TMT-based approach to identify 241 differentially expressed proteins in PRV-infected ISG15 knockout cells, potentially playing important roles in PRV propagation. Validation through RT-qPCR and Western blot confirmed the accuracy of TMT results, while bioinformatics analysis revealed involvement in various biological processes and signaling pathways.

GENES (2021)

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Article Biochemical Research Methods

The Insufficient Activation of RIG-I-Like Signaling Pathway Contributes to Highly Efficient Replication of Porcine Picornaviruses in IBRS-2 Cells

Xiangle Zhang et al.

Summary: By comparing the expression features of IBRS-2 and PK-15 cells in response to SVV infection, differences in innate immune response were identified, with aberrant signal transduction found to be the underlying cause of distinct immune response and viral replication rates between the two cell lines.

MOLECULAR & CELLULAR PROTEOMICS (2021)

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Article Virology

Comparative Proteomic Profiling: Cellular Metabolisms Are Mainly Affected in Senecavirus A-Inoculated Cells at an Early Stage of Infection

Fuxiao Liu et al.

Summary: This study used proteomics and metabolomics methods to investigate the impact of SVA infection on the proteomic profile of BSR-T7/5 cells. It was found that 361 differentially expressed proteins were identified in SVA-infected cells at 12 hours post-inoculation, with 305 upregulated and 56 downregulated proteins. GO and KEGG enrichment analyses indicated that cellular metabolisms were mainly affected in the early stage of SVA infection.

VIRUSES-BASEL (2021)

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Review Virology

Comprehensive review on immunopathogenesis, diagnostic and epidemiology of Senecavirus A

Elizabeth Houston et al.

VIRUS RESEARCH (2020)

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Article Immunology

Transcriptome analysis of senecavirus A-infected cells: Type I interferon is a critical anti-viral factor

Jing Wang et al.

MICROBIAL PATHOGENESIS (2020)

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Article Biochemical Research Methods

Quantitative Proteomic Analysis of Porcine Intestinal Epithelial Cells Infected with Porcine Deltacoronavirus Using iTRAQ-Coupled LC-MS/MS

Xinrong Zhou et al.

JOURNAL OF PROTEOME RESEARCH (2020)

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Article Virology

Evaluation of the 50% Infectious Dose of Human Norovirus Cin-2 in Gnotobiotic Pigs: A Comparison of Classical and Contemporary Methods for Endpoint Estimation

Ashwin K. Ramesh et al.

VIRUSES-BASEL (2020)

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Article Microbiology

E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase

Liang Li et al.

PLOS PATHOGENS (2020)

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Article Microbiology

Seneca Valley Virus 2C and 3Cpro Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway

Tingting Liu et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Phosphoglycerate mutase 1 in cancer: A promising target for diagnosis and therapy

Farzana Sharif et al.

IUBMB LIFE (2019)

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Article Virology

Persistent Infection and Transmission of Senecavirus A from Carrier Sows to Contact Piglets

Mayara F. Maggioli et al.

JOURNAL OF VIROLOGY (2019)

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Review Biochemistry & Molecular Biology

A Review on Quantitative Multiplexed Proteomics

Nishant Pappireddi et al.

CHEMBIOCHEM (2019)

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Article Biochemistry & Molecular Biology

STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

Damian Szklarczyk et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Virology

Porcine Mx1 Protein Inhibits Classical Swine Fever Virus Replication by Targeting Nonstructural Protein NS5B

Jing Zhou et al.

JOURNAL OF VIROLOGY (2018)

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Article Virology

Seneca Valley Virus 3C(pro) abrogates the IRF3-and IRF7-mediated innate immune response by degrading IRF3 and IRF7

Qiao Xue et al.

VIROLOGY (2018)

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Article Virology

Pathogenicity and cross-reactive immune responses of a historical and a contemporary Senecavirus A strains in pigs

Maureen H. Fernandes et al.

VIROLOGY (2018)

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Article Pharmacology & Pharmacy

Seneca Valley Virus 3C protease negatively regulates the type I interferon pathway by acting as a viral deubiquitinase

Qiao Xue et al.

ANTIVIRAL RESEARCH (2018)

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Article Virology

RIG-I is responsible for activation of type I interferon pathway in Seneca Valley virus-infected porcine cells to suppress viral replication

Pengfei Li et al.

VIROLOGY JOURNAL (2018)

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Article Virology

Quantitative analysis of senecavirus A in tissue samples from naturally infected newborn piglets

Alais Maria Dall Agnol et al.

ARCHIVES OF VIROLOGY (2018)

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Review Biochemical Research Methods

Proteomics: Technologies and Their Applications

Bilal Aslam et al.

JOURNAL OF CHROMATOGRAPHIC SCIENCE (2017)

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Article Infectious Diseases

The First Identification and Complete Genome of Senecavirus A Affecting Pig with Idiopathic Vesicular Disease in China

Q. Wu et al.

TRANSBOUNDARY AND EMERGING DISEASES (2017)

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Review Pathology

Senecavirus A: An Emerging Pathogen Causing Vesicular Disease and Mortality in Pigs?

J. Segales et al.

VETERINARY PATHOLOGY (2017)

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Article Virology

Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage

Suhong Qian et al.

JOURNAL OF VIROLOGY (2017)

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Article Pathology

Pathological, Immunohistochemical and Molecular Findings Associated with Senecavirus A-Induced Lesions in Neonatal Piglets

R. A. Leme et al.

JOURNAL OF COMPARATIVE PATHOLOGY (2016)

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Article Infectious Diseases

Neonatal Mortality, Vesicular Lesions and Lameness Associated with Senecavirus A in a US Sow Farm

P. Canning et al.

TRANSBOUNDARY AND EMERGING DISEASES (2016)

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Article Multidisciplinary Sciences

Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins

Chen Zhao et al.

NATURE COMMUNICATIONS (2016)

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Article Immunology

Vesicular Disease in 9-Week-Old Pigs Experimentally Infected with Senecavirus A

Nestor Montiel et al.

EMERGING INFECTIOUS DISEASES (2016)

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Article Virology

Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses

Judith Verhelst et al.

JOURNAL OF VIROLOGY (2015)

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Identification and Complete Genome of Seneca Valley Virus in Vesicular Fluid and Sera of Pigs Affected with Idiopathic Vesicular Disease, Brazil

F. A. Vannucci et al.

TRANSBOUNDARY AND EMERGING DISEASES (2015)

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Review Biochemistry & Molecular Biology

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

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IUBMB LIFE (2012)

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Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly

Judith Verhelst et al.

JOURNAL OF VIROLOGY (2012)

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GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus

Zhijian Yu et al.

ARCHIVES OF VIROLOGY (2008)

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Article Biotechnology & Applied Microbiology

Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus

Laura M. Hales et al.

JOURNAL OF GENERAL VIROLOGY (2008)

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Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method

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METHODS (2001)

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The COG database: a tool for genome-scale analysis of protein functions and evolution

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NUCLEIC ACIDS RESEARCH (2000)

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Comparative Proteomic Analysis Reveals Mx1 Inhibits Senecavirus A Replication in PK-15 Cells by Interacting with the Capsid Proteins VP1, VP2 and VP3

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