☆ 4.6 Article

Exposure Route Influences Disease Severity in the COVID-19 Cynomolgus Macaque Model

VIRUSES-BASEL (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pathology

Laboratory parameters in patients with COVID-19 on first emergency admission is different in non-survivors: albumin and lactate dehydrogenase as risk factors

Maria Salinas et al.

Summary: Prompt identification of the clinical status and severity of COVID-19 can be challenging in the emergency department, but certain laboratory markers such as albumin and LDH have been identified as independent prognostic factors for death, providing valuable guidance for prompt identification of the disease when RT-PCR results are not immediately available.

JOURNAL OF CLINICAL PATHOLOGY (2021)

添加到收藏夹

Article Pathology

Acute Respiratory Distress in Aged, SARS-CoV-2-Infected African Green Monkeys but Not Rhesus Macaques

Robert V. Blair et al.

Summary: This study reported two cases of ARDS in AGMs infected with SARS-CoV-2, as well as a comparatively mild COVID-19 phenotype in two surviving AGMs and four infected RMs. The results suggest that aged AGMs may be useful for modeling severe disease manifestations related to COVID-19.

AMERICAN JOURNAL OF PATHOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure

Sara C. Johnston et al.

Summary: Airborne transmission of SARS-CoV-2 is found to be a prevalent route of human exposure. In a study comparing African green monkeys, rhesus macaques, and cynomolgus macaques exposed to the virus, respiratory abnormalities and viral shedding were observed in all animals. Fever was noted in cynomolgus macaques, while African green monkeys and rhesus macaques experienced thrombocytopenia. The findings suggest that macaques, in addition to African green monkeys, can serve as successful natural transmission models for evaluating medical countermeasures.

PLOS ONE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

Francisco J. Salguero et al.

Summary: This study demonstrates that SARS-CoV-2 replicates in the upper and lower respiratory tract of both rhesus and cynomolgus macaques, causing pulmonary lesions. Immune responses against SARS-CoV-2 are similar in both species, suggesting that both macaque species authentically represent mild to moderate forms of COVID-19. The findings provide valuable insights for evaluating interventions against SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Correlates of protection from SARS-CoV-2 infection

Florian Krammer

LANCET (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters

Julia R. Port et al.

Summary: Port and Yinda et al. directly compared the relative contribution of contact, fomite, and airborne transmission routes of SARS-CoV-2 in Syrian hamsters and found that different routes of exposure lead to distinct disease manifestations. Infection through intranasal and aerosol exposure caused severe respiratory pathology, while fomite exposure resulted in milder disease characterized by an anti-inflammatory immune state and delayed shedding pattern.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Infectious Diseases

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M. Corman et al.

EUROSURVEILLANCE (2020)

添加到收藏夹

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Medicine, General & Internal

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

Nanshan Chen et al.

LANCET (2020)

添加到收藏夹

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

添加到收藏夹

Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Virological assessment of hospitalized patients with COVID-2019

Roman Woelfel et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

Vincent J. Munster et al.

NATURE (2020)

添加到收藏夹

Article Medical Laboratory Technology

Laboratory Findings in COVID-19 Diagnosis and Prognosis

Atieh Pourbagheri-Sigaroodi et al.

CLINICA CHIMICA ACTA (2020)

添加到收藏夹

Article Cell Biology

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Chao Shan et al.

CELL RESEARCH (2020)

添加到收藏夹

Article Critical Care Medicine

Particle sizes of infectious aerosols: implications for infection control

Kevin P. Fennelly

LANCET RESPIRATORY MEDICINE (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Airborne Transmission of SARS-CoV-2 Theoretical Considerations and Available Evidence

Michael Klompas et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Molecular detection of SARS-CoV-2 in formalin-fixed, paraffin-embedded specimens

Jun Liu et al.

JCI INSIGHT (2020)

添加到收藏夹

Review Pathology

A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

Samuel B. Polak et al.

MODERN PATHOLOGY (2020)

添加到收藏夹

Review Microbiology

ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics

Judith A. Hewitt et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques

Wei Deng et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Microbiology

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman et al.

PLOS PATHOGENS (2020)

添加到收藏夹

Editorial Material Critical Care Medicine

y COVID-19 transmission-up in the air

[Anonymous]

LANCET RESPIRATORY MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters

Andrew Chak-Yiu Lee et al.

CELL REPORTS MEDICINE (2020)

添加到收藏夹

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States

Jennifer Harcourt et al.

EMERGING INFECTIOUS DISEASES (2020)

添加到收藏夹

Review Public, Environmental & Occupational Health

2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings

Jane D. Siegel et al.

AMERICAN JOURNAL OF INFECTION CONTROL (2007)

添加到收藏夹

Article Toxicology

Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations

KE Driscoll et al.

TOXICOLOGICAL SCIENCES (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.