Hepatocellular adenoma: Where are we now?

Hepatocellular adenoma (HCA) is a benign hepatocellular neoplasm, commonly occurs in young women with a history of oral contraceptive use. Complications including hemorrhage and malignant transformation necessitate the need for a thorough understanding of the underlying molecular signatures in this entity. Recent molecular studies have significantly expanded our knowledge of HCAs. The well-developed phenotype-genotype classification system improves clinical management through identifying high risk subtype of HCAs. In this article, we attempt to provide updated information on clinical, pathologic and molecular features of each subtype of HCAs.

Automated summary

This article provides updated information on the clinical, pathological, and molecular features of different subtypes of hepatocellular adenoma (HCA), with a focus on the development of a phenotype-genotype classification system to identify high-risk subtypes and improve clinical management.