期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2021.2011405
关键词
Mental health; depression; anxiety; cognition; childhood trauma; cohort study
类别
资金
- Helmholtz Association, German States, German Ministry of Education and Research
Large population-based cohort studies allow for the assessment of various diseases and phenotypes, and the identification of new factors in the onset and course of disease. The German National Cohort focuses on psychiatric disorders and emotional and cognitive functions.
Large population-based cohort studies offer the chance to assess a broad number of diseases and intermediate phenotypes and to estimate their frequencies in the general population. Because of their large sample size new symptom clusters and interactions of genetic, environmental and clinical factors in the onset and course of disease can be described. The German National Cohort (GNC) is one of the mega cohorts with a study-specific concept for the assessment of different psychiatric diseases and a focus on affective disorders and on emotional and cognitive functions. Aim of this manuscript is to describe different design approaches for a priorisation in the assessment of phenotypes for psychiatric and/or neurological disorders in large cohorts and to introduce the concept of studying emotional and cognitive functions and related disorders in GNC.
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