期刊
出版社
WILEY
DOI: 10.1002/wnan.1779
关键词
Cancer; magnetic fluid hyperthermia; magnetic nanoparticles; magnetic particle imaging; theranostics
资金
- National Cancer Institute [1R01 CA257557, 5R01 CA194574-02, 5R01CA247290]
- Jayne Koskinas and Ted Giovanis Foundation for Health and Policy (JKTGF)
- NIH [S10 OD026740, 3EB028904]
- Maryland Stem Cell Fund [MSCRFD5416]
- Philips Healthcare Inc.
- National Institute for Biomedical Imaging and Bioengineering [R44 EB029877]
- School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg
- Brazilian agency CNPq [310230/2017-9]
- Brazilian agency FAPEG [201710267000511]
Magnetic nanomaterials have potential for cancer nanotheranostics, but their physics complexities present challenges. Magnetic fluid hyperthermia (MFH) requires particle-imaging technology for real-time thermometry, and magnetic particle imaging (MPI) is the most promising technology to fulfill this requirement.
Magnetic nanomaterials that respond to clinical magnetic devices have significant potential as cancer nanotheranostics. The complexities of their physics, however, introduce challenges for these applications. Hyperthermia is a heat-based cancer therapy that improves treatment outcomes and patient survival when controlled energy delivery is combined with accurate thermometry. To date, few technologies have achieved the needed evolution for the demands of the clinic. Magnetic fluid hyperthermia (MFH) offers this potential, but to be successful it requires particle-imaging technology that provides real-time thermometry. Presently, the only technology having the potential to meet these requirements is magnetic particle imaging (MPI), for which a proof-of-principle demonstration with MFH has been achieved. Successful clinical translation and adoption of integrated MPI/MFH technology will depend on successful resolution of the technological challenges discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
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