4.8 Article

Prevalence and circulation patterns of SARS-CoV-2 variants in European sewage mirror clinical data of 54 European cities

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Environmental

Spatial and temporal distribution of SARS-CoV-2 diversity circulating in wastewater

Alba Perez-Cataluna et al.

Summary: Wastewater-based epidemiology is an effective tool for epidemiological surveillance of SARS-CoV-2, and when combined with high-throughput sequencing techniques, it can analyze viral diversity. The study proves the ability of sewage sequencing to anticipate mutations and assist in clinical testing for decision-making and analysis of the pandemic's evolution.

WATER RESEARCH (2022)

Letter Medicine, General & Internal

An action plan for pan-European defence against new SARS-CoV-2 variants

Viola Priesemann et al.

LANCET (2021)

News Item Multidisciplinary Sciences

ALARMING COVID VARIANTS SHOW KEY ROLE OF GENOMIC SURVEILLANCE

David Cyranoski

NATURE (2021)

Article Microbiology

Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants

Alexander Crits-Christoph et al.

Summary: Viral genome sequencing, including from wastewater, provides valuable insights into the spread and genetic diversity of SARS-CoV-2 during the COVID-19 pandemic. By analyzing sewage samples, researchers can track specific viral strains and potential introductions of new lineages before they are identified through clinical sequencing.
Article Multidisciplinary Sciences

Identification and molecular characterization of mutations in nucleocapsid phosphoprotein of SARS-CoV-2

Gajendra Kumar Azad

Summary: The study identified 107 mutations in the N-protein of SARS-CoV-2, with 45% of mutations occurring in intrinsically disordered regions. These mutations may significantly alter the stability and dynamics of the N-protein, affecting its functions such as interaction with RNA, oligomerization, and signaling events.
Article Public, Environmental & Occupational Health

Emergence of SARS-CoV-2 B.1.1.7 Lineage — United States, December 29, 2020–January 12, 2021

Summer E. Galloway et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

Article Environmental Sciences

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling

Candice L. Swift et al.

Summary: The study compared wastewater samples from two different wastewater treatment plants in South Carolina, USA, and found that wastewater surveillance can provide earlier community-level detection and detect specific mutations associated with variants of the SARS-CoV-2 virus.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Virology

Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications

Jasdeep B. Singh et al.

Summary: The SARS-CoV-2 virus has undergone multiple mutations during its global circulation, leading to the emergence of three new lineages in the UK, South Africa, and Brazil. These mutations impact crucial proteins such as spike, ORF8, and nucleocapsid, potentially affecting host receptor affinity and antibody resistance.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

Long-term monitoring of SARS-CoV-2 RNA in wastewater of the Frankfurt metropolitan area in Southern Germany

Shelesh Agrawal et al.

Summary: Wastewater-based epidemiology is an effective method to monitor the scale and dynamics of infections in a city, with the SARS-CoV-2 RNA concentration in raw sewage in the Frankfurt metropolitan area showing a resurgence in August. This suggests a continuous increase in COVID-19 cases in Frankfurt.

SCIENTIFIC REPORTS (2021)

Article Engineering, Environmental

High-throughput sequencing of SARS-CoV-2 in wastewater provides insights into circulating variants

Rafaela S. Fontenele et al.

Summary: The study analyzed 91 wastewater samples from 11 states in the USA, detecting a large number of new single-nucleotide variants of SARS-CoV-2, with half of them also being found in subsequent clinical data. The presence of more lineages in wastewater samples suggests a greater genetic diversity circulating within communities compared to clinical-derived data.

WATER RESEARCH (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring

Filipe Pereira

Summary: The SARS-CoV-2 Variant of Concern 202012/01 (VOC-202012/01) is a highly transmissible variant with a potential immune evasion ability due to truncation of the ORF8 gene. Although ORF8-deficient lineages are rare, they have been identified in relevant contexts and should be monitored closely.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Review Biotechnology & Applied Microbiology

SARS-CoV-2 one year on: evidence for ongoing viral adaptation

Thomas P. Peacock et al.

Summary: SARS-CoV-2 virus is believed to have originated from animals and can cause a range of outcomes in humans, from asymptomatic cases to COVID-19. Over a year into the pandemic, the virus continues to mutate, driven by factors such as single nucleotide polymorphisms and insertions/deletions, which may impact its transmissibility and pathogenicity.

JOURNAL OF GENERAL VIROLOGY (2021)

Editorial Material Multidisciplinary Sciences

The emerging plasticity of SARS-CoV-2

Kevin D. McCormick et al.

SCIENCE (2021)

Article Engineering, Environmental

Monitoring SARS-CoV-2 in municipal wastewater to evaluate the success of lockdown measures for controlling COVID-19 in the UK

Luke S. Hillary et al.

Summary: The study demonstrates that SARS-CoV-2 RNA levels in wastewater generally corresponded with the number of clinical cases in large urban centers, decreasing significantly after lockdown measures were implemented. Genetic sequencing of the virus in wastewater revealed multiple distinct clusters circulating in the local population, reflecting similarities with SNPs found in clinical samples. The findings suggest that wastewater-based epidemiology can be a valuable tool for monitoring and tracking the prevalence of SARS-CoV-2 and other viruses in the community, aiding in public health policy decisions.

WATER RESEARCH (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

Irwin Jungreis et al.

Summary: Despite the clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. By comparing 44 Sarbecovirus genomes, a high-confidence protein-coding gene set is provided, characterizing protein-level and nucleotide-level evolutionary constraints, and prioritizing functional mutations from the ongoing COVID-19 pandemic.

NATURE COMMUNICATIONS (2021)

Article Virology

Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2

Sk Sarif Hassan et al.

Summary: ORF3a is a crucial protein in the pathogenesis of COVID-19, with 175 novel mutations identified and categorized into different types based on their impact. The study also analyzed the mutations based on timeline and amino acid compositions, providing insights into the pathogenicity of the virus.

VIRUS RESEARCH (2021)

Review Virology

The Spike of Concern-The Novel Variants of SARS-CoV-2

Anna Winger et al.

Summary: The high sequence identity of the initial SARS-CoV-2 samples collected in Wuhan in December 2019 did not predict the emergence of novel variants in different regions around the world. The viral spike receptor has two areas of high mutagenic plasticity, with mutations mainly focusing on the N-terminal domain and receptor binding domain. The evolution of spike mutations, including the characteristic D614G mutation, continues to drive the development of new variants.

VIRUSES-BASEL (2021)

Article Immunology

Monitoring SARS-CoV-2 Circulation and Diversity through Community Wastewater Sequencing, the Netherlands and Belgium

Ray Izquierdo-Lara et al.

Summary: This study evaluated the diversity of SARS-CoV-2 at the community level in the Netherlands and Belgium using sewage samples, identifying the presence of prevalent clades and clustering of sewage samples with clinical samples from the same region. Additionally, novel mutations in the SARS-CoV-2 genome were detected, illustrating the potential of wastewater surveillance in tracking virus diversity and new outbreaks.

EMERGING INFECTIOUS DISEASES (2021)

Article Microbiology

Metatranscriptomic Analysis Reveals SARS-CoV-2 Mutations in Wastewater of the Frankfurt Metropolitan Area in Southern Germany

Shelesh Agrawal et al.

Summary: Sequencing analysis of SARS-CoV-2 RNA in wastewater samples can provide insights into emerging variants in a city, as most detected mutations have been identified only in clinical genomes outside Frankfurt.

MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2021)

Article Public, Environmental & Occupational Health

Variant analysis of SARS-CoV-2 genomes

Takahiko Koyama et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2020)

Article Microbiology

A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

Andrew Rambaut et al.

NATURE MICROBIOLOGY (2020)

Article Environmental Sciences

First detection of SARS-CoV-2 in untreated wastewaters in Italy

Giuseppina La Rosa et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Immunology

Loss of orf3b in the circulating SARS-CoV-2 strains

Joy-Yan Lam et al.

EMERGING MICROBES & INFECTIONS (2020)

Article Multidisciplinary Sciences

Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations

Hsin-Chou Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Engineering, Environmental

Quantitative CrAssphage PCR Assays for Human Fecal Pollution Measurement

Elyse Stachler et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)