4.5 Article

Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19

期刊

VIROLOGY JOURNAL
卷 19, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12985-022-01786-2

关键词

Coronavirus disease; Lymphocyte subsets; Cytokines

类别

资金

  1. First Batch of Emergency Specialized Scientific Research Fund Projects for Prevention and Control of COVID-19 in Wanzhou [wzstc-202004]

向作者/读者索取更多资源

This study explores the role of lymphocyte subsets and cytokines in predicting the severity of COVID-19. The results showed that ICU patients had lower levels of lymphocyte subsets and higher levels of IL-6 compared to non-ICU patients. The number of CD3(+) T cells and the level of IL-6 on hospital admission may serve as predictive factors for identifying patients with severe disease.
Background Abnormalities of lymphocyte subsets and cytokine profiles have been observed in most patients with coronavirus disease (COVID-19). Here, we explore the role of lymphocyte subsets and cytokines on hospital admission in predicting the severity of COVID-19. Methods This study included 214 patients with COVID-19 who were treated at Chongqing University Three Gorges Hospital from January 19, 2020 to April 30, 2020. Any mutants were not detected in the studied patients. Patients were divided into non-intensive care unit (ICU) (mild/moderate) group and ICU (severe/critical) group, according to the severity of the disease. Clinical and laboratory data, including peripheral lymphocyte subsets and cytokines, were analyzed and compared. Logistic regression was used to analyze the predictive factors for ICU admission. Receiver operating characteristic (ROC) curves were drawn to evaluate the predictive value of selected indicators for the severity of COVID-19. Results Of the 214 patients enrolled, 161 were non-ICU patients and 53 were ICU patients. Lymphopenia was observed in nearly all of ICU patients (96.2%) and 84.5% of non-ICU patients on hospital admission. The absolute number of lymphocytes, CD3(+) T cells, CD4(+) T cells, CD8(+) T cells, CD19(+) B cells, and natural killer (NK) cells were lower in ICU group (659.00 x 10(6)/L, 417.00 x 10(6)/L, 261.00 x 10(6)/L, 140.00 x 10(6)/L, 109.00 x 10(6)/L, 102.00 x 10(6)/L, respectively) than in non-ICU group (1063.00 x 10(9)/L, 717.00 x 10(6)/L, 432.00 x 10(6)/L, 271.00 x 10(6)/L, 133.00 x 10(6)/L, 143.00 x 10(6)/L, respectively). Interleukin (IL)-6 was significantly higher in ICU patients than in non-ICU patients (18.08 pg/mL vs. 3.13 pg/mL, P < 0.001). Multivariate logistic regression analysis showed that age (odds ratio: 1.067 [1.034-1.101]), diabetes mellitus (odds ratio: 9.154 [2.710-30.926]), CD3(+) T cells (odds ratio: 0.996 [0.994-0.997]), and IL-6 (odds ratio: 1.006 [1.000-1.013]) were independent predictors for the development of severe disease. ROC curve analysis showed that the area under the ROC curve (AUC) of CD3(+) T cells and IL-6 was 0.806 (0.737-0.874) and 0.785 (0.705-0.864), respectively, and the cutoff values were 510.50 x 10(6)/L (sensitivity, 71.7%; specificity, 79.5%) and 6.58 pg/mL (77.4%, 74.5%), respectively. There were no statistical differences among all tested indicators of lymphocyte subsets and cytokines between severe group (n = 38) and critical group (n = 15) on hospital admission or ICU admission, respectively. Conclusions The levels of lymphocyte subsets decreased and the level of IL-6 increased significantly in ICU COVID-19 patients compared with non-ICU COVID-19 patients. Therefore, the number of CD3(+) T cells and the level of IL-6 on hospital admission may serve as predictive factors for identifying patients with wild-type virus infection who will have severe disease.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据