期刊
VIROLOGY
卷 568, 期 -, 页码 115-125出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2022.01.012
关键词
Marek's disease virus; Vaccine; Aerosol infection; Chicken; gamma delta T cell; Cytokine; Cytotoxicity
类别
资金
- Natural Sciences and Engineering Research Council of Canada
- Ontario Ministry of Agriculture, Food and Rural Affairs
- UKRI Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Programme [BBS/E/I/00007030]
This study demonstrates that vaccination against Marek's disease virus (MDV) activates effector γδT cells, which may play a crucial role in protective immune responses against MDV.
Marek's disease (MD) vaccines reduce the incidence of MD but cannot control virus shedding. To develop new vaccines, it is essential to elucidate mechanisms of immunity to Marek's disease virus (MDV) infection. In this regard, gamma delta (gamma delta) T cells may play a significant role in prevention of viral spread and tumor surveillance. Here we demonstrated that MDV vaccination induced interferon (IFN)-gamma(+)CD8 alpha(+) gamma delta T cells and transforming growth factor (TGF)-beta(+) gamma delta T cells in lungs. gamma delta T cells from MDV-infected chickens exhibited cytotoxic activity. Importantly, gamma delta T cells from the vaccinated/challenged group exhibited maximum cytotoxic activity following ex vivo stimulation. These results suggest that MDV vaccines activate effector gamma delta T cells which may be involved in the development of protective immune responses against MD. Further, it was demonstrated that MDV infection increases the frequency of a subpopulation of gamma delta T cells expressing membrane-bound TGF-beta in MDV-infected birds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据