期刊
VETERINARY PATHOLOGY
卷 59, 期 3, 页码 427-432出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/03009858221083035
关键词
osteosarcoma; alkaline phosphatase; runx2; dog; immunohistochemistry; surgical pathology; bone; neoplasia
This study evaluated the ability of four immunohistochemistry markers to distinguish osteosarcoma from other primary bone tumors. The combination of alkaline phosphatase (ALP) and runx2 showed high sensitivity and specificity, making them useful for diagnostic purposes.
In dogs, primary bone tumors can be difficult to distinguish with histopathology. Of those tumors, osteosarcoma (OSA) is the most common and aggressive. In this study, 4 immunohistochemistry markers-alkaline phosphatase (ALP), osteonectin (ON), osteopontin (OP), and runx2-were evaluated for their ability to distinguish OSA from other primary bone tumors. The 42 formalin-fixed, paraffin-embedded, primary canine bone tumors included 15 OSAs, 8 chondrosarcomas, 11 fibrosarcomas, and 8 histiocytic sarcomas. All 4 antibodies were highly sensitive for detection of osteosarcoma. ALP was the most sensitive at 100% and runx2 the most specific at 78%. Running ALP and runx2 in series resulted in a sensitivity of 87% and a specificity of 85%. This combination of immunomarkers resulted in a diagnostic panel for distinguishing osteosarcoma from other primary bone tumors.
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