4.4 Article

Brain and pituitary-adrenal lesions of Trypanosoma brucei brucei and Trypanosoma congolense infections in the West African Dwarf rams: Is trypanotolerance overrated?

期刊

VETERINARY PATHOLOGY
卷 59, 期 5, 页码 773-781

出版社

SAGE PUBLICATIONS INC
DOI: 10.1177/03009858221100432

关键词

adrenocorticotrophic hormone; brain; cortisol; parasitic diseases; pituitary-adrenal axis; Trypanosoma brucei; Trypanosoma congolense; trypanotolerance; trypanosomiasis

资金

  1. Institutional Based Research (IBR) grant from Tertiary Education Trust Fund [TETFund/DESS/UNI/NSUKKA/2018/RP/VOL.1]

向作者/读者索取更多资源

This study evaluated the brain, pituitary, and adrenal lesions of Trypanosoma brucei brucei and Trypanosoma congolense infections in West African Dwarf rams. Infected rams showed pathological changes in cortical neurons and Purkinje cells in the brain, as well as degenerative, necrotic, and inflammatory changes in the pituitary and adrenal glands. The levels of adrenocorticotrophic hormone (ACTH) and cortisol were also increased in infected rams.
Trypanosomosis of the West African Dwarf (WAD) sheep is often neglected due to emphasis on trypanotolerance. Nevertheless, significant pathological changes may occur in tissues of infected WAD sheep. The purpose of this study was to evaluate the brain, pituitary, and adrenal lesions of Trypanosoma brucei brucei (Tbb) and Trypanosoma congolense (Tc) infections in WAD rams. Fifteen WAD rams were infected intraperitoneally with Tbb or Tc (10(6) trypanosomes/animal) or were uninfected controls (5 rams per group). Adrenocorticotrophic hormone (ACTH) and cortisol were assayed in serum by enzyme immunoassay technique. The brain, pituitary, and adrenal glands were processed for histopathology. Serum ACTH levels of infected rams were significantly (P < .05) higher than that of controls on days 14 and 70 post infection (PI). Serum cortisol levels of infected rams were significantly (P < .05) higher than that of controls only on day 14 PI. Mortality was 60% in Tbb- and 40% in Tc-infected rams. The brain of the infected groups showed chromatolysis of cortical neurons and Purkinje cells with severe encephalitis. Degenerative, necrotic, and inflammatory changes were seen in the pituitary and adrenal glands of the infected rams. Adrenal corticomedullary ratio was significantly (P < .05) higher in Tc-infected rams than controls. Based on the high mortality levels, likely due to severe encephalitis, the WAD sheep may not be regarded as trypanotolerant.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据