相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Pharmacology & Pharmacy
Rana Abdelnabi et al.
Summary: The infectivity of the omicron variant in hamsters was found to be lower than that of the ancestral D614G strain, with a significant decrease in viral RNA load in the lungs and no detectable infectious virus in this organ. Histopathological examination of the lungs from omicron-infected hamsters revealed no signs of peri-bronchial inflammation or bronchopneumonia.
ANTIVIRAL RESEARCH
(2022)
Letter
Medicine, General & Internal
Caroline Maslo et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Nicole Wolter et al.
Summary: According to data analysis from South Africa, individuals infected with the omicron variant have a lower likelihood of hospitalization compared to those infected with non-omicron variants. Furthermore, individuals infected with the omicron variant have a lower odds of severe disease compared to individuals infected with the earlier delta variant.
Article
Multidisciplinary Sciences
Bo Meng et al.
Summary: The Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 and can evade neutralizing antibodies more effectively compared to the Delta variant. A third dose of mRNA vaccine can provide enhanced protection. Omicron has lower replication in lung and gut cells and less efficiently cleaves its spike protein compared to Delta.
Article
Multidisciplinary Sciences
Sandile Cele et al.
Summary: The study found that the Omicron variant has reduced neutralizing effectiveness in individuals vaccinated with Pfizer BNT162b2, but those who had previously been infected with SARS-CoV-2 showed better neutralization against Omicron.
Article
Multidisciplinary Sciences
Raquel Viana et al.
Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.
Article
Multidisciplinary Sciences
Peter J. Halfmann et al.
Summary: The recent study by the SAVE/NIAID network shows that the B.1.1.529 Omicron variant causes milder lung disease in rodents, which is consistent with preliminary human clinical data.
Article
Medicine, General & Internal
Shabir A. Madhi et al.
Summary: The Omicron variant of SARS-CoV-2 spread more rapidly in South Africa, where two thirds of unvaccinated residents were found to have past infections. Omicron peaked just 1 month after being detected, with hospitalizations and deaths not increasing proportionately with the rise in cases. It remains unclear whether this change is due to widespread preexisting immunity or unique features of the virus.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Sean Wei Xiang Ong et al.
Summary: The study revealed an association between infection with the B.1.617.2 variant and increased disease severity, higher viral loads, and prolonged duration of viral shedding. Vaccination remained protective against severe outcomes.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Katherine A. Twohig et al.
Summary: A study in England found that patients with COVID-19 infected with the delta variant were more likely to be admitted to hospital or attend emergency care compared to those infected with the alpha variant. This suggests that outbreaks of the delta variant in unvaccinated populations may pose a greater burden on healthcare services.
LANCET INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Juliet R. C. Pulliam et al.
Summary: This study provides two methods for monitoring reinfection trends in routine surveillance data. The results suggest immune evasion by the Omicron variant in previously infected individuals in South Africa, and there has been an increase in the risk of having a third infection since mid-November 2021.
Letter
Infectious Diseases
Peter Bager et al.
LANCET INFECTIOUS DISEASES
(2021)
Letter
Multidisciplinary Sciences
Lesley Scott et al.
Article
Public, Environmental & Occupational Health
Waasila Jassat et al.
Summary: The second wave of COVID-19 in South Africa had higher incidence rates, a more rapid increase in hospital admissions, and increased in-hospital mortality compared to the first wave. Individuals admitted in the second wave were more likely to be older, of Mixed race, admitted in the public sector, and had a decreased likelihood of having a comorbid condition. After adjusting for weekly COVID-19 hospital admissions, there was a 31% increased risk of in-hospital mortality in the second wave.
LANCET GLOBAL HEALTH
(2021)
Article
Immunology
Jackie Kleynhans et al.
Summary: Research in South Africa found that SARS-CoV-2 infections may be underestimated, with significant differences in seroprevalence between communities and approximately 95% of infections going unreported. During the second wave, there was a shift in age distribution of cases in urban areas, higher attack rates in rural communities, and a higher infection-fatality ratio in urban areas.
EMERGING INFECTIOUS DISEASES
(2021)
