Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) - a drug used for managing malaria - threatens to interfere with the effective control of malaria. ART resistance ( ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.

Automated summary

Plasmodium falciparum, the cause of malaria, is developing resistance to artemisinin, a drug used to treat malaria, which threatens the effectiveness of malaria control. The development of artemisinin resistance may involve the role of extracellular vesicles in increasing oxidative stress tolerance and reducing the trafficking of hemoglobin to the food vacuole.