Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis

Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19) pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is undoubtedly saving thousands of lives. However, adverse effects (AEs) following vaccination have been noted which may relate to a proinflammatory action of the lipid nanoparticles used or the delivered mRNA (i.e., the vaccine formulation), as well as to the unique nature, expression pattern, binding profile, and proinflammatory effects of the produced antigens - spike (S) protein and/or its subunits/peptide fragments - in human tissues or organs. Current knowledge on this topic originates mostly from cell-based assays or from model organisms; further research on the cellular/molecular basis of the mRNA vaccine-induced AEs will therefore promise safety, maintain trust, and direct health policies.

Automated summary

Vaccination is crucial in controlling the COVID-19 pandemic, and mRNA vaccines are particularly effective. However, adverse effects following vaccination have been observed, which may be related to the vaccine formulation and the inflammatory effects of the antigens produced. It is important to conduct further research on the cellular and molecular basis of these adverse effects to ensure vaccine safety.