期刊
TRENDS IN MICROBIOLOGY
卷 30, 期 12, 页码 1121-1124出版社
CELL PRESS
DOI: 10.1016/j.tim.2022.02.002
关键词
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资金
- National High Technology Research and Development Program of China [2021YFD1400400]
- National Natural Science Foundation of China [32172385, 31760503, 31860491]
- Guizhou Province Technology RD Program [[2019]2398]
DNA methylation is a regulatory mechanism for gene expression under stress conditions. It has been discovered that geminiviruses can enhance the active DNA demethylation mediated by host DNA glycosylases to subvert the DNA methylation-mediated defense, thus enhancing viral virulence. This finding reveals a unique counter-defense strategy employed by invading pathogens for successful infection.
DNA methylation regulates gene expression under abiotic and biotic stresses. Recently, Gui et al. discovered that geminiviruses subverted DNA methylation-mediated defense through boosting the active DNA demethylation mediated by host DNA glycosylases to promote viral virulence. Their findings reveal a distinctive counter-defense strategy exploited by invading pathogens to achieve successful infection.
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