New tools for the new bug Candida auris

Article Microbiology

Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies

Xin Huang et al.

Summary: The study found that Candida auris establishes long-term residence within the skin tissue compartment, evading clinical surveillance, and clades of C. auris from different geographical origins differ in their abilities to colonize murine skin. IL-17 receptor signaling and specific arms of immunity protect mice from long-term C. auris skin colonization, and chlorhexidine antiseptic serves as a protective and decolonizing agent against C. auris.

CELL HOST & MICROBE (2021)

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Article Microbiology

What do we know about the biology of the emerging fungal pathogen of humans Candida auris?

Gustavo Bravo Ruiz et al.

Summary: Candida auris is a fungal pathogen that emerged only a decade ago, and research has focused on understanding its virulence, antifungal resistance, biofilm formation, and interaction with human hosts. Despite some progress, there is still much to learn about this novel pathogen and the development of molecular tools is crucial for further understanding its genetic characteristics and mechanisms of survival.

MICROBIOLOGICAL RESEARCH (2021)

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Article Multidisciplinary Sciences

Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains

Darian J. Santana et al.

Summary: Recent studies have identified that some isolates of Candida auris can form cellular aggregates or filaments, and several genes that regulate its morphogenesis have been identified using transformation and CRISPR-Cas9 system.

NATURE COMMUNICATIONS (2021)

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Article Microbiology

LncRNA DINOR is a virulence factor and global regulator of stress responses in Candida auris

Jiaxin Gao et al.

Summary: This study identified a mutant strain of Candida auris with disrupted long non-coding RNA, DINOR, which plays a role in stress response, morphogenesis, DNA damage, and replication. The upregulation of DINOR is induced by DNA-alkylating agents and exposure to various stressors, indicating its involvement in maintaining genome integrity and orchestrating multiple stress responses. Additionally, genetic interaction studies revealed links between DINOR function and TOR signaling pathway, providing potential insights for therapeutic development against C. auris.

NATURE MICROBIOLOGY (2021)

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Article Microbiology