Inflammatory comorbidities: to train or not to train?

Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells ( HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.

Automated summary

Inflammatory stimuli have a lasting impact on innate immune cells, leading to intensified responses when encountering future challenges. This trained immunity is mediated by hematopoietic stem cells in the bone marrow and is mechanistically linked to inflammatory comorbidities.